exRNAdisease

Entry Detail

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General Information

Database ID: exR0275482 RNA Name: hsa-miR-28-5p RNA Type: miRNA Chromosome: chr3 Starnd: + Coordinate: Start Site(bp): 188688794 End Site(bp): 188688815 External Links: hsa-miR-28-5p

Disease Information

Disease Name: Advanced Adenoma Disease Category: Cancers MeSH ID: D000236 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID: GSE25609 Description: Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening Experimental Design: Cancer vs Control Case Disease Type: Advanced Adenoma Case Disease SubType: NA Case Sample: Advanced Adenoma Post surgery Control Sample: Control Number of Case: 20 Number of Control: 20 Number of Samples: 40

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RTL8A chrX 135050932 135052196 - LYPD3 chr19 43460787 43465608 - RGMA chr15 93035273 93089204 - GLYR1 chr16 4803203 4847288 - E2F6 chr2 11444375 11466177 - PTPN23 chr3 47381011 47413435 + KCTD5 chr16 2682523 2709030 + GPCPD1 chr20 5544439 5611006 - ENSA chr1 150600851 150629612 - AMOTL2 chr3 134355874 134375479 - SSR2 chr1 156009048 156020951 - FAM102A chr9 127940582 127980989 - N4BP1 chr16 48538726 48620148 - CPSF2 chr14 92121969 92172145 + EZH1 chr17 42700275 42745049 - KIAA1522 chr1 32741830 32774970 + LONRF2 chr2 100271875 100322501 - MAPK1 chr22 21754500 21867680 - LASP1 chr17 38869859 38921770 + SMYD1 chr2 88067825 88113384 + NAPA chr19 47487637 47515091 - URGCP chr7 43875894 43926411 - SMG5 chr1 156249224 156282825 - DYRK1A chr21 37365573 37526358 + RTL8B chrX 135020513 135022542 - SLC31A1 chr9 113221544 113264492 + SEH1L chr18 12947133 12987536 + ZBTB7B chr1 155002630 155018522 + TUB chr11 8019244 8106112 + TEX261 chr2 70985942 70994873 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000417 chr12 69644908 69656342 + hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0001164 chr20 45891031 45923523 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009065.4 chr16 2119207 2120248 + AC016876.2 chr17 7581964 7584086 - AC026362.1 chr12 122975320 122982907 + AC118758.3 chr7 56809214 56848800 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE25609 Sample Source: Blood Source Fraction: Plasma Platform: GPL8179 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 826 Sample treatment protocol: Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components. RNA Extract protocol: NA RNA library preparation protocol: Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID: 23267864 Title: Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study Author: Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M Journal: Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3. Description: We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.