exRNAdisease

Entry Detail

---



General Information

Database ID: exR0275499 RNA Name: hsa-miR-302a-3p RNA Type: miRNA Chromosome: chr4 Starnd: - Coordinate: Start Site(bp): 112648186 End Site(bp): 112648208 External Links: hsa-miR-302a-3p

Disease Information

Disease Name: Advanced Adenoma Disease Category: Cancers MeSH ID: D000236 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID: GSE25609 Description: Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening Experimental Design: Cancer vs Control Case Disease Type: Advanced Adenoma Case Disease SubType: NA Case Sample: Advanced Adenoma Post surgery Control Sample: Control Number of Case: 20 Number of Control: 20 Number of Samples: 40

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ZBTB5 chr9 37438102 37465450 - PPP1R8 chr1 27830782 27851676 + ATP6V1C1 chr8 103021063 103073051 + SEC23B chr20 18507520 18561415 + FABP5 chr8 81280536 81284777 + THRAP3 chr1 36224432 36305357 + LONP2 chr16 48244300 48363122 + KLC1 chr14 103561896 103714249 + FAM222B chr17 28755978 28855232 - WASF3 chr13 26557683 26688948 + TOP2A chr17 40388525 40417896 - APP chr21 25880550 26171128 - ARL4A chr7 12686856 12690958 + PDRG1 chr20 31944337 31952046 - SCAMP2 chr15 74843730 74873365 - RAB31 chr18 9708275 9862551 + IKZF4 chr12 56007659 56038435 + RACGAP1 chr12 49976923 50033136 - MGLL chr3 127689062 128052190 - HABP4 chr9 96450169 96491336 + USP6NL chr10 11453946 11611754 - RGMA chr15 93035273 93089204 - JARID2 chr6 15246069 15522042 + BAZ1B chr7 73440406 73522293 - CLIP4 chr2 29097705 29189643 + IPO7 chr11 9384652 9448127 + SEC23IP chr10 119892730 119944657 + VLDLR chr9 2621787 2660056 + IZUMO2 chr19 50152548 50163195 - SSR1 chr6 7268306 7347446 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000943 chr19 47421744 47440665 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC011503.2 chr19 23927788 23929287 + AC125257.1 chr17 41848518 41851447 - AL049840.4 chr14 103694516 103695050 - ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - FGD5-AS1 chr3 14920347 14948424 - MIR17HG chr13 91347820 91354579 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE25609 Sample Source: Blood Source Fraction: Plasma Platform: GPL8179 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 826 Sample treatment protocol: Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components. RNA Extract protocol: NA RNA library preparation protocol: Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID: 23267864 Title: Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study Author: Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M Journal: Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3. Description: We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.