exRNAdisease

Entry Detail

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General Information

Database ID: exR0275531 RNA Name: hsa-miR-324-3p RNA Type: miRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 7223308 End Site(bp): 7223330 External Links: hsa-miR-324-3p

Disease Information

Disease Name: Advanced Adenoma Disease Category: Cancers MeSH ID: D000236 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID: GSE25609 Description: Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening Experimental Design: Cancer vs Control Case Disease Type: Advanced Adenoma Case Disease SubType: NA Case Sample: Advanced Adenoma Post surgery Control Sample: Control Number of Case: 20 Number of Control: 20 Number of Samples: 40

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACLY chr17 41866917 41930542 - ATXN7L3 chr17 44191805 44200113 - CDC42EP2 chr11 65314866 65322417 + CELSR2 chr1 109249539 109275751 + DBNDD1 chr16 90004871 90020128 - DCAF15 chr19 13952492 13961449 + FBXL19 chr16 30923055 30948783 + LNPEP chr5 96935394 97037513 + MAPKAPK2 chr1 206684944 206734283 + MXD4 chr4 2247432 2262109 - NACC1 chr19 13116862 13141147 + PDRG1 chr20 31944337 31952046 - SMAD7 chr18 48919853 48952052 - SPTBN2 chr11 66685248 66729226 - SYVN1 chr11 65121780 65134533 - TAGLN chr11 117199370 117207464 + TNFRSF10B chr8 23020133 23069031 - TULP4 chr6 158232236 158511828 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001727 chr7 99621041 99621930 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC040162.3 chr16 67882461 67886367 + AC234582.1 chr1 155195004 155205495 + KCNQ1OT1 chr11 2608328 2699994 - LINC01521 chr22 31346777 31348719 + MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG22 chr18 49814023 49851059 + Display:

Experiment Detail

GEO ID: GSE25609 Sample Source: Blood Source Fraction: Plasma Platform: GPL8179 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 826 Sample treatment protocol: Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components. RNA Extract protocol: NA RNA library preparation protocol: Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID: 23267864 Title: Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study Author: Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M Journal: Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3. Description: We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.