exRNAdisease

Entry Detail

General Information

Database ID:

exR0275533

RNA Name:

hsa-miR-325

RNA Type:

miRNA

Chromosome:

chrX

Starnd:

-

Coordinate:

Start Site(bp):

77005464

End Site(bp):

77005486

External Links:

Disease Information

Disease Name:	Advanced Adenoma
Disease Category:	Cancers
MeSH ID:	D000236
Type:	Neoplasms/Neoplasms, Glandular and Epithelial
Alias:	Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID:	GSE25609
Description:	Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening
Experimental Design:	Cancer vs Control
Case Disease Type:	Advanced Adenoma
Case Disease SubType:	NA
Case Sample:	Advanced Adenoma Post surgery
Control Sample:	Control
Number of Case:	20
Number of Control:	20
Number of Samples:	40

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ATP6V1A	chr3	113747033	113812056	+
CTTNBP2NL	chr1	112396214	112463456	+
RBFOX2	chr22	35738736	36028824	-
TGOLN2	chr2	85318020	85328296	-

miRNA targets:

NA

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0001867	chr9	86294689	86297981	-
hsa_circ_0001866	chr9	86293355	86297981	-

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC021078.1	chr5	149494314	149504670	-
AC074117.1	chr2	27356246	27367622	+
MAPKAPK5-AS1	chr12	111839764	111842902	-
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE25609
Sample Source:	Blood
Source Fraction:	Plasma
Platform:	GPL8179
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	826
Sample treatment protocol:	Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components.
RNA Extract protocol:	NA
RNA library preparation protocol:	Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID:	23267864
Title:	Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study
Author:	Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M
Journal:	Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3.
Description:	We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.