exRNAdisease

Entry Detail

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General Information

Database ID: exR0275537 RNA Name: hsa-miR-330-3p RNA Type: miRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 45639009 End Site(bp): 45639031 External Links: hsa-miR-330-3p

Disease Information

Disease Name: Advanced Adenoma Disease Category: Cancers MeSH ID: D000236 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID: GSE25609 Description: Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening Experimental Design: Cancer vs Control Case Disease Type: Advanced Adenoma Case Disease SubType: NA Case Sample: Advanced Adenoma Post surgery Control Sample: Control Number of Case: 20 Number of Control: 20 Number of Samples: 40

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ANP32B chr9 97983341 98015943 + ATRX chrX 77504878 77786233 - BCL2L11 chr2 111119378 111168445 + CBX2 chr17 79778148 79787983 + CCSER2 chr10 84328586 84518521 + CRCP chr7 66114604 66154568 + DAG1 chr3 49468703 49535618 + ERLIN1 chr10 100150094 100186033 - GNAI2 chr3 50226292 50259362 + HNRNPAB chr5 178204533 178211163 + MRFAP1 chr4 6640091 6642745 + MTMR12 chr5 32226994 32312987 - NPAT chr11 108157215 108222638 - PFN1 chr17 4945652 4949061 - PKN2 chr1 88684222 88836255 + RAB10 chr2 26034084 26137454 + SNX27 chr1 151612006 151699091 + TNKS chr8 9555912 9782346 + TOMM34 chr20 44942130 44960397 - TRIM25 chr17 56836387 56914080 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000591 chr15 41961025 41962156 + hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001731 chr7 100731990 100738448 + hsa_circ_0001168 chr20 47691321 47707559 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC020978.7 chr16 68224713 68227734 + AC079781.5 chr7 97851688 97972985 - AC124045.1 chr3 44667412 44669364 + AC125257.1 chr17 41848518 41851447 - AL132655.1 chr20 58833809 58836529 - AL137129.1 chr14 61734138 61776260 + AL157392.3 chr10 13631143 13668445 + FGD5-AS1 chr3 14920347 14948424 - MIR663AHG chr20 26167817 26251546 - NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + SNHG25 chr17 64145970 64146476 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE25609 Sample Source: Blood Source Fraction: Plasma Platform: GPL8179 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 826 Sample treatment protocol: Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components. RNA Extract protocol: NA RNA library preparation protocol: Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID: 23267864 Title: Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study Author: Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M Journal: Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3. Description: We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.