exRNAdisease

Entry Detail

---



General Information

Database ID: exR0275640 RNA Name: hsa-miR-485-5p RNA Type: miRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 101055427 End Site(bp): 101055448 External Links: hsa-miR-485-5p

Disease Information

Disease Name: Advanced Adenoma Disease Category: Cancers MeSH ID: D000236 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID: GSE25609 Description: Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening Experimental Design: Cancer vs Control Case Disease Type: Advanced Adenoma Case Disease SubType: NA Case Sample: Advanced Adenoma Post surgery Control Sample: Control Number of Case: 20 Number of Control: 20 Number of Samples: 40

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ZDHHC18 chr1 26826688 26857604 + ZNF106 chr15 42412823 42491141 - IFI6 chr1 27666064 27672198 - FAM102A chr9 127940582 127980989 - SUMF2 chr7 56064002 56080670 + TAOK1 chr17 29390464 29551904 + MAP7D1 chr1 36155579 36180849 + PSKH1 chr16 67893254 67929676 + TSPAN4 chr11 842812 867116 + GOLGA3 chr12 132768914 132829078 - RAB35 chr12 120095099 120117502 - MPDU1 chr17 7583529 7592789 + THY1 chr11 119417378 119424985 - TSR2 chrX 54440404 54448032 + AP1M1 chr19 16197578 16245907 + ARRDC1 chr9 137605685 137615360 + COQ9 chr16 57447425 57461270 + RMI2 chr16 11249619 11381662 + MEPCE chr7 100428790 100434118 + GBF1 chr10 102245532 102382899 + KRT80 chr12 52168996 52192014 - CAPZB chr1 19338775 19485539 - GRHL2 chr8 101492439 101669726 + RHOB chr2 20447074 20449440 + INO80 chr15 40978880 41116280 - ABAT chr16 8674596 8784575 + B4GALT5 chr20 49632945 49713878 - RCC2 chr1 17406760 17439677 - AKT2 chr19 40230317 40285536 - SMAD7 chr18 48919853 48952052 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0000417 chr12 69644908 69656342 + hsa_circ_0000798 chr17 65941524 65944422 + hsa_circ_0000552 chr14 71880664 71948928 + hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0000799 chr17 65941524 65972074 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005899.4 chr17 32328441 32329395 + AC016065.1 chr8 6403551 6407142 - AC016355.1 chr15 67541072 67542604 - AC016876.2 chr17 7581964 7584086 - AC026362.1 chr12 122975320 122982907 + AC069281.2 chr7 100572232 100578700 - AC074117.1 chr2 27356246 27367622 + AC118758.3 chr7 56809214 56848800 - AL022311.1 chr22 37876148 37895563 + AL132655.2 chr20 58817132 58817725 - AP000662.1 chr11 57638024 57652790 + COL4A2-AS2 chr13 110456396 110463287 - GAS5 chr1 173858559 173868882 - LINC00265 chr7 39733430 39793092 + LINC01278 chrX 63222993 63561095 - LINC01772 chr1 16460948 16468481 + MALAT1 chr11 65497688 65506516 + MIR29B2CHG chr1 207801518 207879115 - NEAT1 chr11 65422774 65445540 + NUTM2A-AS1 chr10 87201647 87342612 - SNHG16 chr17 76557764 76565348 + SNHG3 chr1 28505980 28510892 + XIST chrX 73820649 73852723 - ZFHX2-AS1 chr14 23511760 23560778 + Display:

Experiment Detail

GEO ID: GSE25609 Sample Source: Blood Source Fraction: Plasma Platform: GPL8179 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 826 Sample treatment protocol: Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components. RNA Extract protocol: NA RNA library preparation protocol: Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID: 23267864 Title: Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study Author: Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M Journal: Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3. Description: We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.