exRNAdisease

Entry Detail

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General Information

Database ID: exR0275659 RNA Name: hsa-miR-497-5p RNA Type: miRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 7017979 End Site(bp): 7017999 External Links: hsa-miR-497-5p

Disease Information

Disease Name: Advanced Adenoma Disease Category: Cancers MeSH ID: D000236 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID: GSE25609 Description: Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening Experimental Design: Cancer vs Control Case Disease Type: Advanced Adenoma Case Disease SubType: NA Case Sample: Advanced Adenoma Post surgery Control Sample: Control Number of Case: 20 Number of Control: 20 Number of Samples: 40

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ARRDC4 chr15 97960703 97973833 + ZNF664 chr12 123971845 124015439 + ANKRD17 chr4 73073376 73258798 - ZBTB34 chr9 126860665 126885878 + PLAGL1 chr6 143940300 144064599 - PDE4A chr19 10416773 10469630 + ITPR1 chr3 4493345 4847840 + ARHGDIA chr17 81867721 81871378 - PRKACA chr19 14091688 14118084 - STEAP3 chr2 119223831 119265652 + AMER1 chrX 64185117 64205708 - PLPP6 chr9 4662294 4665258 + KMT2D chr12 49018975 49059774 - JARID2 chr6 15246069 15522042 + RGS3 chr9 113444731 113597743 + ANKRD13B chr17 29589769 29614761 + MINDY2 chr15 58771192 58861900 + TBRG1 chr11 124622836 124635926 + BIRC5 chr17 78214186 78225636 + PKN2 chr1 88684222 88836255 + GFPT1 chr2 69319769 69387254 - PIK3R1 chr5 68215756 68301821 + UNC119B chr12 120710458 120723640 + ATP6V0B chr1 43974487 43978295 + MAPK1IP1L chr14 55051647 55070194 + LITAF chr16 11547722 11636381 - TSC22D2 chr3 150408335 150466431 + MLEC chr12 120687149 120701859 + KDSR chr18 63327726 63367228 - AADAT chr4 170060222 170091699 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001005 chr2 53921020 53978078 - hsa_circ_0001723 chr7 91924202 91948826 + hsa_circ_0000458 chr12 124071293 124074996 + hsa_circ_0001699 chr7 40027197 40041630 + hsa_circ_0001387 chr4 1902352 1936989 + hsa_circ_0001168 chr20 47691321 47707559 + hsa_circ_0000552 chr14 71880664 71948928 + hsa_circ_0000038 chr1 28800065 28802803 + hsa_circ_0000652 chr15 90984737 90986710 + hsa_circ_0001472 chr5 36953719 36976504 + hsa_circ_0001263 chr3 5215701 5216099 + hsa_circ_0000799 chr17 65941524 65972074 + hsa_circ_0001164 chr20 45891031 45923523 - hsa_circ_0000032 chr1 25666964 25669564 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand FGD5-AS1 chr3 14920347 14948424 - AP000317.2 chr21 34073592 34360033 + MCM3AP-AS1 chr21 46229196 46259390 + AC079781.5 chr7 97851688 97972985 - MIR503HG chrX 134543119 134546642 - AC114980.1 chr5 93860669 93863825 - NUTM2A-AS1 chr10 87201647 87342612 - LINC02035 chr3 122886941 122892416 + MIR497HG chr17 7015818 7019659 - MZF1-AS1 chr19 58559129 58574797 + LINC01184 chr5 127939152 128083172 - AL031282.2 chr1 1702736 1737688 - SNHG16 chr17 76557764 76565348 + AC002470.2 chr22 20979462 20998121 + XIST chrX 73820649 73852723 - AL359924.1 chr1 237862175 237928321 + AC003092.1 chr7 94022833 94066661 + LINC00649 chr21 33915534 33977691 + HCG18 chr6 30286690 30327382 - LINC00662 chr19 27681072 27794005 - AL391244.1 chr1 1420245 1422691 + STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + MIR29B2CHG chr1 207801518 207879115 - AC021078.1 chr5 149494314 149504670 - AC020978.7 chr16 68224713 68227734 + AC009022.1 chr16 69976297 70065948 - NEAT1 chr11 65422774 65445540 + SNHG12 chr1 28578538 28583132 - SNHG1 chr11 62851984 62855953 - AC021092.1 chr19 44103007 44113183 - Display:

Experiment Detail

GEO ID: GSE25609 Sample Source: Blood Source Fraction: Plasma Platform: GPL8179 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 826 Sample treatment protocol: Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components. RNA Extract protocol: NA RNA library preparation protocol: Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID: 23267864 Title: Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study Author: Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M Journal: Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3. Description: We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.