exRNAdisease

Entry Detail

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General Information

Database ID: exR0275694 RNA Name: hsa-miR-516b-5p RNA Type: miRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 53736860 End Site(bp): 53736881 External Links: hsa-miR-516b-5p

Disease Information

Disease Name: Advanced Adenoma Disease Category: Cancers MeSH ID: D000236 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID: GSE25609 Description: Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening Experimental Design: Cancer vs Control Case Disease Type: Advanced Adenoma Case Disease SubType: NA Case Sample: Advanced Adenoma Post surgery Control Sample: Control Number of Case: 20 Number of Control: 20 Number of Samples: 40

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand BCL2L11 chr2 111119378 111168445 + CHKB-CPT1B chr22 50568869 50582965 - CPT1B chr22 50568861 50578465 - DNAJC9 chr10 73183362 73247255 - FAM13B chr5 137937960 138051961 - FNBP4 chr11 47716494 47767443 - FOSL2 chr2 28392448 28417317 + FSD1 chr19 4304598 4323843 + GOLGA1 chr9 124878275 124948492 - HIF1AN chr10 100529072 100559998 + MAK16 chr8 33485182 33501262 + NEMP1 chr12 57055643 57088063 - NID1 chr1 235975830 236065109 - PIGS chr17 28553383 28571794 - QSER1 chr11 32892820 32993316 + RABGAP1 chr9 122940833 123104866 + S100A16 chr1 153606886 153613145 - SGPP1 chr14 63684216 63728065 - STAT3 chr17 42313324 42388568 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000698 chr16 47531309 47549512 + hsa_circ_0001727 chr7 99621041 99621930 + hsa_circ_0001495 chr5 68470703 68471364 + hsa_circ_0000825 chr18 8718421 8720494 + hsa_circ_0001387 chr4 1902352 1936989 + hsa_circ_0000038 chr1 28800065 28802803 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AC079781.5 chr7 97851688 97972985 - AL157392.3 chr10 13631143 13668445 + COL4A2-AS2 chr13 110456396 110463287 - LINC00324 chr17 8220642 8224043 - LINC01184 chr5 127939152 128083172 - MIR194-2HG chr11 64889560 64893449 - NEAT1 chr11 65422774 65445540 + PCBP1-AS1 chr2 69962263 70103220 - TBC1D3P1-DHX40P1 chr17 59962363 60018975 - TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE25609 Sample Source: Blood Source Fraction: Plasma Platform: GPL8179 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 826 Sample treatment protocol: Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components. RNA Extract protocol: NA RNA library preparation protocol: Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID: 23267864 Title: Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study Author: Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M Journal: Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3. Description: We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.