exRNAdisease

Entry Detail

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General Information

Database ID: exR0275719 RNA Name: hsa-miR-520a-3p RNA Type: miRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 53690933 End Site(bp): 53690954 External Links: hsa-miR-520a-3p

Disease Information

Disease Name: Advanced Adenoma Disease Category: Cancers MeSH ID: D000236 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID: GSE25609 Description: Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening Experimental Design: Cancer vs Control Case Disease Type: Advanced Adenoma Case Disease SubType: NA Case Sample: Advanced Adenoma Post surgery Control Sample: Control Number of Case: 20 Number of Control: 20 Number of Samples: 40

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand SEMA3C chr7 80742538 80922359 - APP chr21 25880550 26171128 - IKZF4 chr12 56007659 56038435 + MAGI3 chr1 113390515 113685923 + HTD2 chr3 58306262 58318574 + RPP14 chr3 58306247 58324695 + CELF2 chr10 10798397 11336675 + SLC7A2 chr8 17497088 17570573 + SYAP1 chrX 16719612 16765340 + FYCO1 chr3 45917899 45995824 - PDRG1 chr20 31944337 31952046 - OCRL chrX 129539849 129592561 + CLIP4 chr2 29097705 29189643 + COL4A2 chr13 110305812 110513209 + CDK6 chr7 92604921 92836594 - PLAGL2 chr20 32192504 32207743 - CLCN6 chr1 11806096 11848079 + MNT chr17 2384073 2401104 - XRRA1 chr11 74807739 74949200 - ZFAND4 chr10 45615500 45672780 - CCDC93 chr2 117915478 118014133 - UCHL1 chr4 41256413 41268455 + MSL1 chr17 40121971 40136917 + RACGAP1 chr12 49976923 50033136 - KIAA1522 chr1 32741830 32774970 + BTN3A1 chr6 26402237 26415208 + MBP chr18 76978827 77133683 - RGMA chr15 93035273 93089204 - CUL1 chr7 148697914 148801110 + TRIM37 chr17 58982638 59106921 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000943 chr19 47421744 47440665 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC125257.1 chr17 41848518 41851447 - AL049840.4 chr14 103694516 103695050 - ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - FGD5-AS1 chr3 14920347 14948424 - MIR17HG chr13 91347820 91354579 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE25609 Sample Source: Blood Source Fraction: Plasma Platform: GPL8179 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 826 Sample treatment protocol: Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components. RNA Extract protocol: NA RNA library preparation protocol: Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID: 23267864 Title: Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study Author: Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M Journal: Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3. Description: We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.