exRNAdisease

Entry Detail

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General Information

Database ID: exR0275801 RNA Name: hsa-miR-574-5p RNA Type: miRNA Chromosome: chr4 Starnd: + Coordinate: Start Site(bp): 38868056 End Site(bp): 38868078 External Links: hsa-miR-574-5p

Disease Information

Disease Name: Advanced Adenoma Disease Category: Cancers MeSH ID: D000236 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID: GSE25609 Description: Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening Experimental Design: Cancer vs Control Case Disease Type: Advanced Adenoma Case Disease SubType: NA Case Sample: Advanced Adenoma Post surgery Control Sample: Control Number of Case: 20 Number of Control: 20 Number of Samples: 40

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CCDC88C chr14 91271323 91417844 - CARMIL1 chr6 25279078 25620530 + AHCYL1 chr1 109984765 110023742 + ARID3A chr19 925781 975939 + CHD7 chr8 60678740 60868028 + IDH3A chr15 78131498 78171945 + FAM102A chr9 127940582 127980989 - EEF2K chr16 22206278 22288738 + LRP8 chr1 53242364 53328469 - SMCO4 chr11 93478472 93543391 - ALDOA chr16 30064164 30070457 + ZNF621 chr3 40524878 40574685 + MAP7D1 chr1 36155579 36180849 + RAB10 chr2 26034084 26137454 + TACC1 chr8 38728186 38853028 + KLF11 chr2 10042849 10054836 + TEAD1 chr11 12674421 12944737 + MGRN1 chr16 4616493 4690974 + SLC9A1 chr1 27098809 27166981 - FNDC3A chr13 48975912 49209779 + SLC25A43 chrX 119399336 119454478 + CTSD chr11 1752755 1764573 - PHF20L1 chr8 132775358 132848807 + DCAF8 chr1 160215715 160262549 - PIK3R3 chr1 46040140 46133036 - RHOU chr1 228735479 228746664 + GALNT3 chr2 165747588 165794659 - HOXC8 chr12 54008985 54012769 + NID1 chr1 235975830 236065109 - WSB2 chr12 118032694 118062430 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005394.2 chr19 28435388 28727680 - AC021092.1 chr19 44103007 44113183 - AL358472.3 chr1 153966516 153966930 + DSCAM-AS1 chr21 40383083 40385358 + NEAT1 chr11 65422774 65445540 + SNHG7 chr9 136721366 136728184 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE25609 Sample Source: Blood Source Fraction: Plasma Platform: GPL8179 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 826 Sample treatment protocol: Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components. RNA Extract protocol: NA RNA library preparation protocol: Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID: 23267864 Title: Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study Author: Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M Journal: Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3. Description: We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.