exRNAdisease

Entry Detail

General Information

Database ID:

exR0275810

RNA Name:

hsa-miR-582-3p

RNA Type:

miRNA

Chromosome:

chr5

Starnd:

-

Coordinate:

Start Site(bp):

59703630

End Site(bp):

59703651

External Links:

Disease Information

Disease Name:	Advanced Adenoma
Disease Category:	Cancers
MeSH ID:	D000236
Type:	Neoplasms/Neoplasms, Glandular and Epithelial
Alias:	Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID:	GSE25609
Description:	Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening
Experimental Design:	Cancer vs Control
Case Disease Type:	Advanced Adenoma
Case Disease SubType:	NA
Case Sample:	Advanced Adenoma Post surgery
Control Sample:	Control
Number of Case:	20
Number of Control:	20
Number of Samples:	40

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
HACD3	chr15	65530418	65578349	+
INO80D	chr2	205993721	206086303	-
MPV17	chr2	27309492	27325680	-
SLC26A2	chr5	149960758	149993455	+
TCF12	chr15	56918623	57299281	+

miRNA targets:

NA

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0000417	chr12	69644908	69656342	+
hsa_circ_0000642	chr15	80390757	80415142	+
hsa_circ_0000643	chr15	80412669	80415142	+
hsa_circ_0000155	chr1	168007608	168014465	+

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
DSCAM-AS1	chr21	40383083	40385358	+
NEAT1	chr11	65422774	65445540	+
ZFAS1	chr20	49278178	49299600	+

Display:

Experiment Detail

GEO ID:	GSE25609
Sample Source:	Blood
Source Fraction:	Plasma
Platform:	GPL8179
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	826
Sample treatment protocol:	Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components.
RNA Extract protocol:	NA
RNA library preparation protocol:	Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID:	23267864
Title:	Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study
Author:	Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M
Journal:	Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3.
Description:	We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.