exRNAdisease

Entry Detail

General Information

Database ID:

exR0275819

RNA Name:

hsa-miR-589-5p

RNA Type:

miRNA

Chromosome:

chr7

Starnd:

-

Coordinate:

Start Site(bp):

5495873

End Site(bp):

5495894

External Links:

Disease Information

Disease Name:	Advanced Adenoma
Disease Category:	Cancers
MeSH ID:	D000236
Type:	Neoplasms/Neoplasms, Glandular and Epithelial
Alias:	Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID:	GSE25609
Description:	Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening
Experimental Design:	Cancer vs Control
Case Disease Type:	Advanced Adenoma
Case Disease SubType:	NA
Case Sample:	Advanced Adenoma Post surgery
Control Sample:	Control
Number of Case:	20
Number of Control:	20
Number of Samples:	40

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC007192.1	chr19	18153158	18178117	+
ATP6V0D1	chr16	67438014	67481181	-
FXYD3	chr19	35115879	35124324	+
JPT2	chr16	1678256	1702280	+
MICU1	chr10	72367327	72626191	-
NFIX	chr19	12995608	13098796	+
PACS1	chr11	66070272	66244744	+
PIK3R2	chr19	18153163	18170532	+
RNF169	chr11	74748849	74842413	+
SEC61A1	chr3	128051641	128071683	+
WDR45B	chr17	82614562	82648553	-

miRNA targets:

NA

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0001134	chr20	21319681	21324846	+

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC016876.2	chr17	7581964	7584086	-
AC027290.2	chr12	122865335	122867021	+
KCNQ1OT1	chr11	2608328	2699994	-
MALAT1	chr11	65497688	65506516	+

Display:

Experiment Detail

GEO ID:	GSE25609
Sample Source:	Blood
Source Fraction:	Plasma
Platform:	GPL8179
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	826
Sample treatment protocol:	Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components.
RNA Extract protocol:	NA
RNA library preparation protocol:	Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID:	23267864
Title:	Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study
Author:	Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M
Journal:	Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3.
Description:	We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.