exRNAdisease

General Information

Database ID:

exR0275901

RNA Name:

hsa-miR-663a

RNA Type:

miRNA

Chromosome:

chr20

Starnd:

Coordinate:

Start Site(bp):

26208243

End Site(bp):

26208264

External Links:

Disease Information

Disease Name:	Advanced Adenoma
Disease Category:	Cancers
MeSH ID:	D000236
Type:	Neoplasms/Neoplasms, Glandular and Epithelial
Alias:	Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID:	GSE25609
Description:	Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening
Experimental Design:	Cancer vs Control
Case Disease Type:	Advanced Adenoma
Case Disease SubType:	NA
Case Sample:	Advanced Adenoma Post surgery
Control Sample:	Control
Number of Case:	20
Number of Control:	20
Number of Samples:	40

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
COL6A2	chr21	46098112	46132848	+
KLC2	chr11	66257294	66267860	+
REXO1	chr19	1815248	1848483	-
MIDN	chr19	1248553	1259140	+
STK35	chr20	2101827	2177038	+
MIGA2	chr9	129036621	129072082	+
SRPRA	chr11	126262938	126269144	-
KDM2A	chr11	67119263	67258082	+
JUNB	chr19	12791486	12793315	+
GNB1	chr1	1785285	1891117	-
SYVN1	chr11	65121780	65134533	-
SCN1B	chr19	35030470	35040449	+
SMAD3	chr15	67063763	67195169	+
HIF1AN	chr10	100529072	100559998	+
TNRC6A	chr16	24610209	24827632	+
ARHGAP1	chr11	46677080	46700619	-
ARL8A	chr1	202133404	202144743	-
PPDPF	chr20	63520765	63522206	+
KMT5A	chr12	123383773	123409353	+
RTL8A	chrX	135050932	135052196	-
SOX12	chr20	325595	330224	+
CYB5R3	chr22	42617840	42649392	-
PRR12	chr19	49591182	49626439	+
CAPN15	chr16	527712	554636	+
DMWD	chr19	45782947	45792845	-
BOC	chr3	113211003	113287459	+
FAM83H	chr8	143723933	143738234	-
CLSTN1	chr1	9728926	9823984	-
CALR	chr19	12938578	12944489	+
CMIP	chr16	81445170	81711762	+

miRNA targets:

circRNA targets:

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC008738.7	chr19	33207129	33207639	+
AC020928.2	chr19	36773712	36775908	-
AC069281.2	chr7	100572232	100578700	-
AC234582.1	chr1	155195004	155205495	+
AL137127.1	chr1	19072110	19075511	-
AL355075.4	chr14	20343048	20343685	-
AL356488.2	chr1	109100193	109100619	+
GAS5	chr1	173858559	173868882	-
MIR663AHG	chr20	26167817	26251546	-
NEAT1	chr11	65422774	65445540	+
NORAD	chr20	36045618	36051018	-
SNHG25	chr17	64145970	64146476	+
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE25609
Sample Source:	Blood
Source Fraction:	Plasma
Platform:	GPL8179
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	826
Sample treatment protocol:	Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components.
RNA Extract protocol:	NA
RNA library preparation protocol:	Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID:	23267864
Title:	Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study
Author:	Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M
Journal:	Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3.
Description:	We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.