exRNAdisease

Entry Detail

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General Information

Database ID: exR0275923 RNA Name: hsa-miR-769-5p RNA Type: miRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 46018961 End Site(bp): 46018982 External Links: hsa-miR-769-5p

Disease Information

Disease Name: Advanced Adenoma Disease Category: Cancers MeSH ID: D000236 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID: GSE25609 Description: Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening Experimental Design: Cancer vs Control Case Disease Type: Advanced Adenoma Case Disease SubType: NA Case Sample: Advanced Adenoma Post surgery Control Sample: Control Number of Case: 20 Number of Control: 20 Number of Samples: 40

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACVR1B chr12 51951699 51997078 + ANGEL1 chr14 76786168 76826246 - ASB1 chr2 238426742 238452250 + BMPR2 chr2 202376327 202567751 + CAPNS1 chr19 36139953 36150353 + CBFB chr16 67028984 67101058 + CLDN11 chr3 170418865 170454733 + CLN8 chr8 1755778 1801711 + DBNDD1 chr16 90004871 90020128 - DCTN4 chr5 150708440 150759109 - EIF1AD chr11 65996545 66002176 - EIF1AX chrX 20124525 20141838 - FOXK1 chr7 4682295 4771442 + LONRF2 chr2 100271875 100322501 - MDM4 chr1 204516379 204558120 + MRTO4 chr1 19251805 19260128 + NUSAP1 chr15 41320794 41381050 + PLCD3 chr17 45108959 45133354 - PRKAA1 chr5 40759379 40798374 - PXN chr12 120210439 120265771 - RHPN1 chr8 143368876 143384221 + RUNX1 chr21 34787801 36004667 - TFAP4 chr16 4257186 4273075 - VAT1 chr17 43014607 43025123 - YPEL5 chr2 30146941 30160533 + ZDHHC9 chrX 129803288 129843909 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC245033.4 chr15 82533175 82540008 - LINC00324 chr17 8220642 8224043 - MALAT1 chr11 65497688 65506516 + SNHG1 chr11 62851984 62855953 - Display:

Experiment Detail

GEO ID: GSE25609 Sample Source: Blood Source Fraction: Plasma Platform: GPL8179 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 826 Sample treatment protocol: Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components. RNA Extract protocol: NA RNA library preparation protocol: Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID: 23267864 Title: Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study Author: Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M Journal: Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3. Description: We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.