exRNAdisease

Entry Detail

---



General Information

Database ID: exR0275926 RNA Name: hsa-miR-873-5p RNA Type: miRNA Chromosome: chr9 Starnd: - Coordinate: Start Site(bp): 28888925 End Site(bp): 28888945 External Links: hsa-miR-873-5p

Disease Information

Disease Name: Advanced Adenoma Disease Category: Cancers MeSH ID: D000236 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID: GSE25609 Description: Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening Experimental Design: Cancer vs Control Case Disease Type: Advanced Adenoma Case Disease SubType: NA Case Sample: Advanced Adenoma Post surgery Control Sample: Control Number of Case: 20 Number of Control: 20 Number of Samples: 40

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CACUL1 chr10 118674167 118755249 - ICAM1 chr19 10271093 10286615 + IDS chrX 149476988 149521096 - NUDT3 chr6 34279679 34392669 - EPHA4 chr2 221418027 221574202 - TRIOBP chr22 37697048 37776556 + BCL2L11 chr2 111119378 111168445 + SEPHS2 chr16 30443631 30445874 - PFKFB3 chr10 6144934 6254644 + PSD3 chr8 18527303 19084730 - PRDM15 chr21 41798225 41879482 - DLG3 chrX 70444835 70505490 + ORAI1 chr12 121626550 121642677 + LMBR1 chr7 156668946 156893216 - TRIO chr5 14143342 14532128 + OTUB1 chr11 63985853 64001811 + HDGF chr1 156742109 156766925 - FAM222B chr17 28755978 28855232 - TBX3 chr12 114670255 114684175 - BCL9L chr11 118893875 118925608 - CTTNBP2NL chr1 112396214 112463456 + CENPX chr17 82018702 82024107 - SMG5 chr1 156249224 156282825 - PLAGL2 chr20 32192504 32207743 - BICRA chr19 47608196 47703277 + CSNK1E chr22 38290691 38318084 - TMEM179B chr11 62787402 62790400 + DBNDD1 chr16 90004871 90020128 - ZXDB chrX 57591652 57597545 + APPL2 chr12 105173297 105236203 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000417 chr12 69644908 69656342 + hsa_circ_0000987 chr2 30748452 30756180 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC002116.1 chr19 36008638 36014235 - AC079781.5 chr7 97851688 97972985 - AC084809.2 chr17 32905662 32906584 + AC239868.1 chr1 149861271 149862504 + AC245033.4 chr15 82533175 82540008 - AL022311.1 chr22 37876148 37895563 + AL049543.1 chr6 28587378 28591747 + AL355987.2 chr9 136800366 136829466 + GAS5 chr1 173858559 173868882 - LINC01535 chr19 37251885 37265535 + MALAT1 chr11 65497688 65506516 + MIR4435-2HG chr2 111006015 111523376 - MIR503HG chrX 134543119 134546642 - NEAT1 chr11 65422774 65445540 + SNHG15 chr7 44983023 44986961 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE25609 Sample Source: Blood Source Fraction: Plasma Platform: GPL8179 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 826 Sample treatment protocol: Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components. RNA Extract protocol: NA RNA library preparation protocol: Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID: 23267864 Title: Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study Author: Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M Journal: Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3. Description: We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.