exRNAdisease

Entry Detail

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General Information

Database ID: exR0286457 RNA Name: hsa-miR-103a-3p RNA Type: miRNA Chromosome: chr5 Starnd: - Coordinate: Start Site(bp): 168560904 End Site(bp): 168560926 External Links: hsa-miR-103a-3p

Disease Information

Disease Name: Drug-induced Liver Injury Disease Category: Digestive System Diseases MeSH ID: D056486 Type: Diseases Category/Digestive System Diseases Alias: Chemical and Drug Induced Liver Injury//Chemically-Induced Liver Toxicity//Chemically Induced Liver Toxicity//Chemically-Induced Liver Toxicities//Liver Toxicities, Chemically-Induced//Liver Toxicity, Chemically-Induced//Toxicities, Chemically-Induced Liver//Toxicity, Chemically-Induced Liver//Drug-Induced Acute Liver Injury//Drug Induced Acute Liver Injury//Liver Injury, Drug-Induced, Acute//Acute Liver Injury, Drug-Induced//Acute Liver Injury, Drug Induced//Hepatitis, Toxic//Toxic Hepatitis//Hepatitides, Toxic//Toxic Hepatitides//Drug-Induced Liver Disease//Disease, Drug-Induced Liver//Diseases, Drug-Induced Liver//Drug Induced Liver Disease//Drug-Induced Liver Diseases//Liver Disease, Drug-Induced//Liver Diseases, Drug-Induced//Drug-Induced Liver Injury//Drug Induced Liver Injury//Drug-Induced Liver Injuries//Injuries, Drug-Induced Liver//Injury, Drug-Induced Liver//Liver Injuries, Drug-Induced//Liver Injury, Drug-Induced//Liver Injury, Drug Induced//Hepatitis, Drug-Induced//Drug-Induced Hepatitides//Drug-Induced Hepatitis//Hepatitides, Drug-Induced//Hepatitis, Drug Induced

Expression Detail

GEO ID: GSE59565 Description: Circulating miRNAs of acetaminophen-overdosed patients Experimental Design: Accidental Acetaminophen Overdose Case Disease Type: Drug-induced Liver Injury Case Disease SubType: NA Case Sample: Healthy with APAP Overdose Control Sample: Healthy Number of Case: 18 Number of Control: 6 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RCCD1 chr15 90954870 90963125 + CA12 chr15 63321378 63381846 - AMER1 chrX 64185117 64205708 - PLPP6 chr9 4662294 4665258 + ERG28 chr14 75649791 75660876 - SCAMP4 chr19 1905372 1926013 + DPP3 chr11 66480013 66509657 + AC011455.2 chr19 38915404 38949855 - UBN1 chr16 4846665 4882401 + TMX2 chr11 57712593 57740973 + RNF157 chr17 76142465 76240493 - NAA60 chr16 3443649 3486953 + MRPS2 chr9 135499984 135504673 + TSPYL2 chrX 53082367 53088540 + KLHL21 chr1 6590724 6614607 - TUBA1B chr12 49127782 49131397 - STEAP3 chr2 119223831 119265652 + MRPL3 chr3 131462212 131502983 - STK16 chr2 219245455 219250337 + ABCF2 chr7 151207837 151227166 - RPS6KA3 chrX 20149911 20267519 - DCAF7 chr17 63550477 63594279 + CNN2 chr19 1026586 1039068 + SRPK1 chr6 35832966 35921342 - ZNF697 chr1 119619377 119648266 - LYSMD2 chr15 51723011 51751585 - PODXL chr7 131500262 131558217 - EBP chrX 48521799 48528716 + RPS14 chr5 150442635 150449739 - PKM chr15 72199029 72231822 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000712 chr16 68208276 68225678 + hsa_circ_0001723 chr7 91924202 91948826 + hsa_circ_0001495 chr5 68470703 68471364 + hsa_circ_0001168 chr20 47691321 47707559 + hsa_circ_0000652 chr15 90984737 90986710 + hsa_circ_0001472 chr5 36953719 36976504 + hsa_circ_0001164 chr20 45891031 45923523 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC003092.1 chr7 94022833 94066661 + AC018521.1 chr17 47945424 47981736 + AC021078.1 chr5 149494314 149504670 - AC021092.1 chr19 44103007 44113183 - AC093297.2 chr5 44826076 44828592 + AL137127.1 chr1 19072110 19075511 - FGD5-AS1 chr3 14920347 14948424 - H19 chr11 1995176 2001470 - LINC00294 chr11 33076149 33079454 + LINC00662 chr19 27681072 27794005 - LINC02035 chr3 122886941 122892416 + MIR503HG chrX 134543119 134546642 - NEAT1 chr11 65422774 65445540 + NUTM2A-AS1 chr10 87201647 87342612 - NUTM2B-AS1 chr10 79661394 79826594 - STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + TMEM147-AS1 chr19 35540738 35546029 - TTC28-AS1 chr22 27919376 28008581 + TTN-AS1 chr2 178521183 178779963 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE59565 Sample Source: Blood Source Fraction: Serum Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2545 Sample treatment protocol: Serum samples were recovered from serum-separator tubes following centrifugation of whole blood at 3000×g for 10 minutes at room temperature. RNA Extract protocol: Serum miRNA was isolated using the miRNeasy Mini Kit (QUIAGEN, CA, USA) RNA library preparation protocol: TruSeq Small RNA-Seq Preparation Kit (Illumina, CA, USA)

Reference

PMID: 25359176 Title: Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury Author: Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC Journal: Toxicol Sci. 2015 Feb;143(2):268-76. Description: Upon applying next generation high-throughput sequencing of small RNA libraries, 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs were relevant to APAP toxic mechanisms.