exRNAdisease

Entry Detail

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General Information

Database ID: exR0286516 RNA Name: hsa-miR-1323 RNA Type: miRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 53671978 End Site(bp): 53671999 External Links: hsa-miR-1323

Disease Information

Disease Name: Drug-induced Liver Injury Disease Category: Digestive System Diseases MeSH ID: D056486 Type: Diseases Category/Digestive System Diseases Alias: Chemical and Drug Induced Liver Injury//Chemically-Induced Liver Toxicity//Chemically Induced Liver Toxicity//Chemically-Induced Liver Toxicities//Liver Toxicities, Chemically-Induced//Liver Toxicity, Chemically-Induced//Toxicities, Chemically-Induced Liver//Toxicity, Chemically-Induced Liver//Drug-Induced Acute Liver Injury//Drug Induced Acute Liver Injury//Liver Injury, Drug-Induced, Acute//Acute Liver Injury, Drug-Induced//Acute Liver Injury, Drug Induced//Hepatitis, Toxic//Toxic Hepatitis//Hepatitides, Toxic//Toxic Hepatitides//Drug-Induced Liver Disease//Disease, Drug-Induced Liver//Diseases, Drug-Induced Liver//Drug Induced Liver Disease//Drug-Induced Liver Diseases//Liver Disease, Drug-Induced//Liver Diseases, Drug-Induced//Drug-Induced Liver Injury//Drug Induced Liver Injury//Drug-Induced Liver Injuries//Injuries, Drug-Induced Liver//Injury, Drug-Induced Liver//Liver Injuries, Drug-Induced//Liver Injury, Drug-Induced//Liver Injury, Drug Induced//Hepatitis, Drug-Induced//Drug-Induced Hepatitides//Drug-Induced Hepatitis//Hepatitides, Drug-Induced//Hepatitis, Drug Induced

Expression Detail

GEO ID: GSE59565 Description: Circulating miRNAs of acetaminophen-overdosed patients Experimental Design: Accidental Acetaminophen Overdose Case Disease Type: Drug-induced Liver Injury Case Disease SubType: NA Case Sample: Healthy with APAP Overdose Control Sample: Healthy Number of Case: 18 Number of Control: 6 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABCC5 chr3 183919934 184017939 - CAMTA1 chr1 6785454 7769706 + CDK6 chr7 92604921 92836594 - CDKN1B chr12 12715058 12722369 + CELSR2 chr1 109249539 109275751 + DCAF7 chr17 63550477 63594279 + NFAT5 chr16 69565094 69704666 + PLEKHM1 chr17 45435900 45490749 - PPP1R3C chr10 91628442 91633071 - RAB8A chr19 16111889 16134234 + ZNF618 chr9 113876282 114056591 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000712 chr16 68208276 68225678 + hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0001151 chr20 35236117 35236221 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AC022167.2 chr16 8848105 8860456 + FGD5-AS1 chr3 14920347 14948424 - GAS5 chr1 173858559 173868882 - LINC00662 chr19 27681072 27794005 - MALAT1 chr11 65497688 65506516 + MCM3AP-AS1 chr21 46229196 46259390 + MIR17HG chr13 91347820 91354579 + NEAT1 chr11 65422774 65445540 + NUTM2A-AS1 chr10 87201647 87342612 - OIP5-AS1 chr15 41283990 41309737 + SNHG15 chr7 44983023 44986961 - TUG1 chr22 30969245 30979395 + ZFAS1 chr20 49278178 49299600 + Display:

Experiment Detail

GEO ID: GSE59565 Sample Source: Blood Source Fraction: Serum Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2545 Sample treatment protocol: Serum samples were recovered from serum-separator tubes following centrifugation of whole blood at 3000×g for 10 minutes at room temperature. RNA Extract protocol: Serum miRNA was isolated using the miRNeasy Mini Kit (QUIAGEN, CA, USA) RNA library preparation protocol: TruSeq Small RNA-Seq Preparation Kit (Illumina, CA, USA)

Reference

PMID: 25359176 Title: Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury Author: Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC Journal: Toxicol Sci. 2015 Feb;143(2):268-76. Description: Upon applying next generation high-throughput sequencing of small RNA libraries, 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs were relevant to APAP toxic mechanisms.