exRNAdisease

Entry Detail

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General Information

Database ID: exR0286521 RNA Name: hsa-miR-138-5p RNA Type: miRNA Chromosome: chr16 Starnd: + Coordinate: Start Site(bp): 56858527 End Site(bp): 56858549 External Links: hsa-miR-138-5p

Disease Information

Disease Name: Drug-induced Liver Injury Disease Category: Digestive System Diseases MeSH ID: D056486 Type: Diseases Category/Digestive System Diseases Alias: Chemical and Drug Induced Liver Injury//Chemically-Induced Liver Toxicity//Chemically Induced Liver Toxicity//Chemically-Induced Liver Toxicities//Liver Toxicities, Chemically-Induced//Liver Toxicity, Chemically-Induced//Toxicities, Chemically-Induced Liver//Toxicity, Chemically-Induced Liver//Drug-Induced Acute Liver Injury//Drug Induced Acute Liver Injury//Liver Injury, Drug-Induced, Acute//Acute Liver Injury, Drug-Induced//Acute Liver Injury, Drug Induced//Hepatitis, Toxic//Toxic Hepatitis//Hepatitides, Toxic//Toxic Hepatitides//Drug-Induced Liver Disease//Disease, Drug-Induced Liver//Diseases, Drug-Induced Liver//Drug Induced Liver Disease//Drug-Induced Liver Diseases//Liver Disease, Drug-Induced//Liver Diseases, Drug-Induced//Drug-Induced Liver Injury//Drug Induced Liver Injury//Drug-Induced Liver Injuries//Injuries, Drug-Induced Liver//Injury, Drug-Induced Liver//Liver Injuries, Drug-Induced//Liver Injury, Drug-Induced//Liver Injury, Drug Induced//Hepatitis, Drug-Induced//Drug-Induced Hepatitides//Drug-Induced Hepatitis//Hepatitides, Drug-Induced//Hepatitis, Drug Induced

Expression Detail

GEO ID: GSE59565 Description: Circulating miRNAs of acetaminophen-overdosed patients Experimental Design: Accidental Acetaminophen Overdose Case Disease Type: Drug-induced Liver Injury Case Disease SubType: NA Case Sample: Healthy with APAP Overdose Control Sample: Healthy Number of Case: 18 Number of Control: 6 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand KRT80 chr12 52168996 52192014 - STX3 chr11 59713456 59805882 + SIN3A chr15 75369379 75455842 - RNH1 chr11 494512 507300 - ACTN4 chr19 38647649 38731589 + CDCA7L chr7 21900899 21945903 - COPS7B chr2 231781671 231809254 + LARP4B chr10 806914 931705 - GSK3A chr19 42230190 42242625 - GNAI2 chr3 50226292 50259362 + NINJ1 chr9 93121496 93134251 - IGF2BP1 chr17 48997385 49056145 + TFAP2A chr6 10393186 10419659 - FOXC1 chr6 1609915 1613897 + PATL1 chr11 59636716 59669037 - SRF chr6 43171269 43181506 + MAFG chr17 81918270 81927735 - AHDC1 chr1 27534035 27604431 - FOXP4 chr6 41546426 41602384 + HIF1AN chr10 100529072 100559998 + PRKACA chr19 14091688 14118084 - SMG1 chr16 18804853 18926454 - IQGAP1 chr15 90388242 90502239 + CTDSP1 chr2 218398256 218405941 + HMGA1 chr6 34236873 34246231 + KLF11 chr2 10042849 10054836 + ZHX2 chr8 122781655 122974510 + IQSEC1 chr3 12897043 13283281 - PLXNB2 chr22 50274979 50307646 - TRIB1 chr8 125430358 125438403 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0000402 chr12 53670403 53671011 + hsa_circ_0000798 chr17 65941524 65944422 + hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0000799 chr17 65941524 65972074 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC092718.4 chr16 81030770 81031485 + AC144548.1 chr12 110387463 110445548 - AL137127.1 chr1 19072110 19075511 - H19 chr11 1995176 2001470 - MCF2L-AS1 chr13 112967484 112968824 - MCM3AP-AS1 chr21 46229196 46259390 + NEAT1 chr11 65422774 65445540 + PARD6G-AS1 chr18 80147924 80179839 + STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + TUG1 chr22 30969245 30979395 + TFAP2A-AS1 chr6 10409340 10416446 + Display:

Experiment Detail

GEO ID: GSE59565 Sample Source: Blood Source Fraction: Serum Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2545 Sample treatment protocol: Serum samples were recovered from serum-separator tubes following centrifugation of whole blood at 3000×g for 10 minutes at room temperature. RNA Extract protocol: Serum miRNA was isolated using the miRNeasy Mini Kit (QUIAGEN, CA, USA) RNA library preparation protocol: TruSeq Small RNA-Seq Preparation Kit (Illumina, CA, USA)

Reference

PMID: 25359176 Title: Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury Author: Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC Journal: Toxicol Sci. 2015 Feb;143(2):268-76. Description: Upon applying next generation high-throughput sequencing of small RNA libraries, 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs were relevant to APAP toxic mechanisms.