exRNAdisease

Entry Detail

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General Information

Database ID: exR0286553 RNA Name: hsa-miR-155-5p RNA Type: miRNA Chromosome: chr21 Starnd: + Coordinate: Start Site(bp): 25573983 End Site(bp): 25574006 External Links: hsa-miR-155-5p

Disease Information

Disease Name: Drug-induced Liver Injury Disease Category: Digestive System Diseases MeSH ID: D056486 Type: Diseases Category/Digestive System Diseases Alias: Chemical and Drug Induced Liver Injury//Chemically-Induced Liver Toxicity//Chemically Induced Liver Toxicity//Chemically-Induced Liver Toxicities//Liver Toxicities, Chemically-Induced//Liver Toxicity, Chemically-Induced//Toxicities, Chemically-Induced Liver//Toxicity, Chemically-Induced Liver//Drug-Induced Acute Liver Injury//Drug Induced Acute Liver Injury//Liver Injury, Drug-Induced, Acute//Acute Liver Injury, Drug-Induced//Acute Liver Injury, Drug Induced//Hepatitis, Toxic//Toxic Hepatitis//Hepatitides, Toxic//Toxic Hepatitides//Drug-Induced Liver Disease//Disease, Drug-Induced Liver//Diseases, Drug-Induced Liver//Drug Induced Liver Disease//Drug-Induced Liver Diseases//Liver Disease, Drug-Induced//Liver Diseases, Drug-Induced//Drug-Induced Liver Injury//Drug Induced Liver Injury//Drug-Induced Liver Injuries//Injuries, Drug-Induced Liver//Injury, Drug-Induced Liver//Liver Injuries, Drug-Induced//Liver Injury, Drug-Induced//Liver Injury, Drug Induced//Hepatitis, Drug-Induced//Drug-Induced Hepatitides//Drug-Induced Hepatitis//Hepatitides, Drug-Induced//Hepatitis, Drug Induced

Expression Detail

GEO ID: GSE59565 Description: Circulating miRNAs of acetaminophen-overdosed patients Experimental Design: Accidental Acetaminophen Overdose Case Disease Type: Drug-induced Liver Injury Case Disease SubType: NA Case Sample: Healthy with APAP Overdose Control Sample: Healthy Number of Case: 18 Number of Control: 6 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TSC22D4 chr7 100463359 100479232 - ACOT7 chr1 6264269 6394391 - MRFAP1 chr4 6640091 6642745 + SH3KBP1 chrX 19533977 19887600 - NUFIP2 chr17 29255839 29294148 - CENPM chr22 41938737 41947152 - SP100 chr2 230415942 230545606 + ARL3 chr10 102673731 102714397 - JAK1 chr1 64833229 65067754 - LAPTM4A chr2 20032650 20051628 - SOD2 chr6 159669069 159745186 - HNRNPLL chr2 38561969 38603586 - LCP1 chr13 46125920 46211871 - AICDA chr12 8602170 8612867 - CD52 chr1 26317958 26320523 + MFSD9 chr2 102714630 102736888 - NDUFA4 chr7 10931943 10940153 - CHEK2 chr22 28687743 28742422 - ZMYM5 chr13 19823482 19863649 - PGLS chr19 17511636 17521288 + CCNB1 chr5 69167135 69178245 + IL2RG chrX 71107404 71112108 - CXXC1 chr18 50282343 50288304 - RBM38 chr20 57391396 57409333 + CFL1 chr11 65823022 65862026 - PPM1B chr2 44167969 44244384 + ZFP36 chr19 39406847 39409412 + FTL chr19 48965309 48966879 + ERH chr14 69380128 69398299 - VPS18 chr15 40894450 40903975 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000642 chr15 80390757 80415142 + hsa_circ_0000892 chr19 11941431 12014514 + hsa_circ_0001046 chr2 97024782 97033111 + hsa_circ_0000643 chr15 80412669 80415142 + hsa_circ_0000698 chr16 47531309 47549512 + hsa_circ_0001146 chr20 34241449 34246936 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC021078.1 chr5 149494314 149504670 - AC090198.1 chr8 124488510 124491643 + AC245033.4 chr15 82533175 82540008 - AL022311.1 chr22 37876148 37895563 + ELOA-AS1 chr1 23706901 23778296 - GABPB1-AS1 chr15 50354959 50372202 + LINC00240 chr6 26956932 27059749 + LINC01772 chr1 16460948 16468481 + MALAT1 chr11 65497688 65506516 + MIR155HG chr21 25561909 25575168 + MIR17HG chr13 91347820 91354579 + NORAD chr20 36045618 36051018 - OIP5-AS1 chr15 41283990 41309737 + SNHG5 chr6 85650491 85678932 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE59565 Sample Source: Blood Source Fraction: Serum Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2545 Sample treatment protocol: Serum samples were recovered from serum-separator tubes following centrifugation of whole blood at 3000×g for 10 minutes at room temperature. RNA Extract protocol: Serum miRNA was isolated using the miRNeasy Mini Kit (QUIAGEN, CA, USA) RNA library preparation protocol: TruSeq Small RNA-Seq Preparation Kit (Illumina, CA, USA)

Reference

PMID: 25359176 Title: Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury Author: Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC Journal: Toxicol Sci. 2015 Feb;143(2):268-76. Description: Upon applying next generation high-throughput sequencing of small RNA libraries, 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs were relevant to APAP toxic mechanisms.