exRNAdisease

Entry Detail

---



General Information

Database ID: exR0286606 RNA Name: hsa-miR-205-5p RNA Type: miRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 209432166 End Site(bp): 209432187 External Links: hsa-miR-205-5p

Disease Information

Disease Name: Drug-induced Liver Injury Disease Category: Digestive System Diseases MeSH ID: D056486 Type: Diseases Category/Digestive System Diseases Alias: Chemical and Drug Induced Liver Injury//Chemically-Induced Liver Toxicity//Chemically Induced Liver Toxicity//Chemically-Induced Liver Toxicities//Liver Toxicities, Chemically-Induced//Liver Toxicity, Chemically-Induced//Toxicities, Chemically-Induced Liver//Toxicity, Chemically-Induced Liver//Drug-Induced Acute Liver Injury//Drug Induced Acute Liver Injury//Liver Injury, Drug-Induced, Acute//Acute Liver Injury, Drug-Induced//Acute Liver Injury, Drug Induced//Hepatitis, Toxic//Toxic Hepatitis//Hepatitides, Toxic//Toxic Hepatitides//Drug-Induced Liver Disease//Disease, Drug-Induced Liver//Diseases, Drug-Induced Liver//Drug Induced Liver Disease//Drug-Induced Liver Diseases//Liver Disease, Drug-Induced//Liver Diseases, Drug-Induced//Drug-Induced Liver Injury//Drug Induced Liver Injury//Drug-Induced Liver Injuries//Injuries, Drug-Induced Liver//Injury, Drug-Induced Liver//Liver Injuries, Drug-Induced//Liver Injury, Drug-Induced//Liver Injury, Drug Induced//Hepatitis, Drug-Induced//Drug-Induced Hepatitides//Drug-Induced Hepatitis//Hepatitides, Drug-Induced//Hepatitis, Drug Induced

Expression Detail

GEO ID: GSE59565 Description: Circulating miRNAs of acetaminophen-overdosed patients Experimental Design: Accidental Acetaminophen Overdose Case Disease Type: Drug-induced Liver Injury Case Disease SubType: NA Case Sample: Healthy with APAP Overdose Control Sample: Healthy Number of Case: 18 Number of Control: 6 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand DOCK6 chr19 11199295 11262524 - MKRN2 chr3 12557087 12583713 + NUP93 chr16 56730118 56850286 + EP300 chr22 41092592 41180077 + CDC42 chr1 22025511 22101360 + LSM1 chr8 38163335 38176730 - TSPYL4 chr6 116249964 116254075 - HINT1 chr5 131159027 131171735 - YTHDF2 chr1 28736621 28769775 + PPP3CC chr8 22440819 22541142 + SLTM chr15 58879050 58933679 - RUNX1T1 chr8 91954967 92103286 - CALM3 chr19 46601074 46610782 + PRKCSH chr19 11435288 11450968 + SFPQ chr1 35176378 35193145 - PLXNA1 chr3 126988594 127037392 + KAZN chr1 13892792 15118043 + OGDH chr7 44606572 44709066 + ZCCHC8 chr12 122471599 122501073 - SLC25A3 chr12 98593591 98606379 + AFF4 chr5 132875395 132963634 - CAPZA2 chr7 116811070 116922049 + SLC3A2 chr11 62856102 62888875 + ACSL1 chr4 184755595 184826818 - XRCC6 chr22 41621119 41664048 + NDUFAF1 chr15 41387353 41402519 - SOSTDC1 chr7 16461481 16530580 - E2F1 chr20 33675477 33686385 - CCZ1B chr7 6794134 6826770 - GNPDA2 chr4 44682200 44726588 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001434 chr4 106345352 106377902 - hsa_circ_0001731 chr7 100731990 100738448 + hsa_circ_0000733 chr17 1561546 1562030 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009133.5 chr16 29808679 29812227 + GAS5 chr1 173858559 173868882 - MALAT1 chr11 65497688 65506516 + MCM3AP-AS1 chr21 46229196 46259390 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG16 chr17 76557764 76565348 + SNHG5 chr6 85650491 85678932 - AL356133.1 chr9 26801733 26805862 + Display:

Experiment Detail

GEO ID: GSE59565 Sample Source: Blood Source Fraction: Serum Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2545 Sample treatment protocol: Serum samples were recovered from serum-separator tubes following centrifugation of whole blood at 3000×g for 10 minutes at room temperature. RNA Extract protocol: Serum miRNA was isolated using the miRNeasy Mini Kit (QUIAGEN, CA, USA) RNA library preparation protocol: TruSeq Small RNA-Seq Preparation Kit (Illumina, CA, USA)

Reference

PMID: 25359176 Title: Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury Author: Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC Journal: Toxicol Sci. 2015 Feb;143(2):268-76. Description: Upon applying next generation high-throughput sequencing of small RNA libraries, 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs were relevant to APAP toxic mechanisms.