exRNAdisease

Entry Detail

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General Information

Database ID: exR0286623 RNA Name: hsa-miR-22-3p RNA Type: miRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 1713914 End Site(bp): 1713935 External Links: hsa-miR-22-3p

Disease Information

Disease Name: Drug-induced Liver Injury Disease Category: Digestive System Diseases MeSH ID: D056486 Type: Diseases Category/Digestive System Diseases Alias: Chemical and Drug Induced Liver Injury//Chemically-Induced Liver Toxicity//Chemically Induced Liver Toxicity//Chemically-Induced Liver Toxicities//Liver Toxicities, Chemically-Induced//Liver Toxicity, Chemically-Induced//Toxicities, Chemically-Induced Liver//Toxicity, Chemically-Induced Liver//Drug-Induced Acute Liver Injury//Drug Induced Acute Liver Injury//Liver Injury, Drug-Induced, Acute//Acute Liver Injury, Drug-Induced//Acute Liver Injury, Drug Induced//Hepatitis, Toxic//Toxic Hepatitis//Hepatitides, Toxic//Toxic Hepatitides//Drug-Induced Liver Disease//Disease, Drug-Induced Liver//Diseases, Drug-Induced Liver//Drug Induced Liver Disease//Drug-Induced Liver Diseases//Liver Disease, Drug-Induced//Liver Diseases, Drug-Induced//Drug-Induced Liver Injury//Drug Induced Liver Injury//Drug-Induced Liver Injuries//Injuries, Drug-Induced Liver//Injury, Drug-Induced Liver//Liver Injuries, Drug-Induced//Liver Injury, Drug-Induced//Liver Injury, Drug Induced//Hepatitis, Drug-Induced//Drug-Induced Hepatitides//Drug-Induced Hepatitis//Hepatitides, Drug-Induced//Hepatitis, Drug Induced

Expression Detail

GEO ID: GSE59565 Description: Circulating miRNAs of acetaminophen-overdosed patients Experimental Design: Accidental Acetaminophen Overdose Case Disease Type: Drug-induced Liver Injury Case Disease SubType: NA Case Sample: Healthy with APAP Overdose Control Sample: Healthy Number of Case: 18 Number of Control: 6 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CCDC97 chr19 41310172 41324873 + AP1S1 chr7 101154456 101161596 + RCOR1 chr14 102592649 102730561 + RAB11FIP4 chr17 31391675 31538211 + PPIF chr10 79347469 79355334 + FBXL19 chr16 30923055 30948783 + FNBP4 chr11 47716494 47767443 - DCP1A chr3 53283429 53347586 - GDAP1 chr8 74321130 74488872 + WSB2 chr12 118032694 118062430 - ITGA5 chr12 54395261 54419266 - IRS2 chr13 109752695 109786583 - FOXP1 chr3 70952817 71583993 - TMEM179B chr11 62787402 62790400 + ETS1 chr11 128458761 128587558 - ATP2C1 chr3 130850595 131016712 + ZNF740 chr12 53180704 53195142 + CACUL1 chr10 118674167 118755249 - ATP6V0B chr1 43974487 43978295 + ACLY chr17 41866917 41930542 - CLASP1 chr2 121337776 121649587 - PRLR chr5 35048756 35230487 - PDPR chr16 70113626 70162537 + WWC2 chr4 183099257 183320777 + TAGLN chr11 117199370 117207464 + BCL9 chr1 147541501 147626216 + GLIS2 chr16 4314761 4339597 + GBF1 chr10 102245532 102382899 + PDSS1 chr10 26697701 26746798 + RANBP2 chr2 108719482 108785809 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001699 chr7 40027197 40041630 + hsa_circ_0001414 chr4 56277780 56284152 + hsa_circ_0000733 chr17 1561546 1562030 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC021078.1 chr5 149494314 149504670 - AL360012.1 chr1 28648600 28648730 + MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - OIP5-AS1 chr15 41283990 41309737 + SNHG16 chr17 76557764 76565348 + Display:

Experiment Detail

GEO ID: GSE59565 Sample Source: Blood Source Fraction: Serum Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2545 Sample treatment protocol: Serum samples were recovered from serum-separator tubes following centrifugation of whole blood at 3000×g for 10 minutes at room temperature. RNA Extract protocol: Serum miRNA was isolated using the miRNeasy Mini Kit (QUIAGEN, CA, USA) RNA library preparation protocol: TruSeq Small RNA-Seq Preparation Kit (Illumina, CA, USA)

Reference

PMID: 25359176 Title: Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury Author: Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC Journal: Toxicol Sci. 2015 Feb;143(2):268-76. Description: Upon applying next generation high-throughput sequencing of small RNA libraries, 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs were relevant to APAP toxic mechanisms.