exRNAdisease

Entry Detail

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General Information

Database ID: exR0286675 RNA Name: hsa-miR-31-5p RNA Type: miRNA Chromosome: chr9 Starnd: - Coordinate: Start Site(bp): 21512158 End Site(bp): 21512178 External Links: hsa-miR-31-5p

Disease Information

Disease Name: Drug-induced Liver Injury Disease Category: Digestive System Diseases MeSH ID: D056486 Type: Diseases Category/Digestive System Diseases Alias: Chemical and Drug Induced Liver Injury//Chemically-Induced Liver Toxicity//Chemically Induced Liver Toxicity//Chemically-Induced Liver Toxicities//Liver Toxicities, Chemically-Induced//Liver Toxicity, Chemically-Induced//Toxicities, Chemically-Induced Liver//Toxicity, Chemically-Induced Liver//Drug-Induced Acute Liver Injury//Drug Induced Acute Liver Injury//Liver Injury, Drug-Induced, Acute//Acute Liver Injury, Drug-Induced//Acute Liver Injury, Drug Induced//Hepatitis, Toxic//Toxic Hepatitis//Hepatitides, Toxic//Toxic Hepatitides//Drug-Induced Liver Disease//Disease, Drug-Induced Liver//Diseases, Drug-Induced Liver//Drug Induced Liver Disease//Drug-Induced Liver Diseases//Liver Disease, Drug-Induced//Liver Diseases, Drug-Induced//Drug-Induced Liver Injury//Drug Induced Liver Injury//Drug-Induced Liver Injuries//Injuries, Drug-Induced Liver//Injury, Drug-Induced Liver//Liver Injuries, Drug-Induced//Liver Injury, Drug-Induced//Liver Injury, Drug Induced//Hepatitis, Drug-Induced//Drug-Induced Hepatitides//Drug-Induced Hepatitis//Hepatitides, Drug-Induced//Hepatitis, Drug Induced

Expression Detail

GEO ID: GSE59565 Description: Circulating miRNAs of acetaminophen-overdosed patients Experimental Design: Accidental Acetaminophen Overdose Case Disease Type: Drug-induced Liver Injury Case Disease SubType: NA Case Sample: Healthy with APAP Overdose Control Sample: Healthy Number of Case: 18 Number of Control: 6 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABHD4 chr14 22598237 22613215 + ANKRD52 chr12 56237807 56258384 - BACH2 chr6 89926528 90296908 - CHD1 chr5 98853985 98928957 - CTNND1 chr11 57753243 57819546 + FAM222B chr17 28755978 28855232 - FURIN chr15 90868588 90883458 + GRK2 chr11 67266473 67286556 + HACD3 chr15 65530418 65578349 + HOXA7 chr7 27153716 27157936 - KIF3B chr20 32277651 32335011 + LONRF1 chr8 12721906 12756073 - MAP3K14 chr17 45263119 45317029 - PATL1 chr11 59636716 59669037 - PLCB1 chr20 8077251 8968360 + PPP1R3C chr10 91628442 91633071 - PRRC2B chr9 131373636 131500197 + RTL8B chrX 135020513 135022542 - RTL8C chrX 135032355 135033546 + SERF2 chr15 43777087 43802589 + SMAD3 chr15 67063763 67195169 + TRIM35 chr8 27284886 27311272 - XPNPEP3 chr22 40857077 40932815 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001728 chr7 99695763 99695845 - hsa_circ_0001349 chr3 152132729 152150709 + hsa_circ_0000241 chr10 70847874 70856944 + hsa_circ_0000931 chr19 38226804 38231095 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004832.5 chr22 30420512 30420912 + AC016876.2 chr17 7581964 7584086 - AC074117.1 chr2 27356246 27367622 + AC087477.2 chr15 96354237 96405235 + GAS5 chr1 173858559 173868882 - MAGI2-AS3 chr7 79452877 79471208 + MIR497HG chr17 7015818 7019659 - NEAT1 chr11 65422774 65445540 + SNHG16 chr17 76557764 76565348 + TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE59565 Sample Source: Blood Source Fraction: Serum Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2545 Sample treatment protocol: Serum samples were recovered from serum-separator tubes following centrifugation of whole blood at 3000×g for 10 minutes at room temperature. RNA Extract protocol: Serum miRNA was isolated using the miRNeasy Mini Kit (QUIAGEN, CA, USA) RNA library preparation protocol: TruSeq Small RNA-Seq Preparation Kit (Illumina, CA, USA)

Reference

PMID: 25359176 Title: Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury Author: Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC Journal: Toxicol Sci. 2015 Feb;143(2):268-76. Description: Upon applying next generation high-throughput sequencing of small RNA libraries, 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs were relevant to APAP toxic mechanisms.