exRNAdisease

Entry Detail

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General Information

Database ID: exR0286700 RNA Name: hsa-miR-320d RNA Type: miRNA Chromosome: chr13 Starnd: - Coordinate: Start Site(bp): 40727828 End Site(bp): 40727846 External Links: hsa-miR-320d

Disease Information

Disease Name: Drug-induced Liver Injury Disease Category: Digestive System Diseases MeSH ID: D056486 Type: Diseases Category/Digestive System Diseases Alias: Chemical and Drug Induced Liver Injury//Chemically-Induced Liver Toxicity//Chemically Induced Liver Toxicity//Chemically-Induced Liver Toxicities//Liver Toxicities, Chemically-Induced//Liver Toxicity, Chemically-Induced//Toxicities, Chemically-Induced Liver//Toxicity, Chemically-Induced Liver//Drug-Induced Acute Liver Injury//Drug Induced Acute Liver Injury//Liver Injury, Drug-Induced, Acute//Acute Liver Injury, Drug-Induced//Acute Liver Injury, Drug Induced//Hepatitis, Toxic//Toxic Hepatitis//Hepatitides, Toxic//Toxic Hepatitides//Drug-Induced Liver Disease//Disease, Drug-Induced Liver//Diseases, Drug-Induced Liver//Drug Induced Liver Disease//Drug-Induced Liver Diseases//Liver Disease, Drug-Induced//Liver Diseases, Drug-Induced//Drug-Induced Liver Injury//Drug Induced Liver Injury//Drug-Induced Liver Injuries//Injuries, Drug-Induced Liver//Injury, Drug-Induced Liver//Liver Injuries, Drug-Induced//Liver Injury, Drug-Induced//Liver Injury, Drug Induced//Hepatitis, Drug-Induced//Drug-Induced Hepatitides//Drug-Induced Hepatitis//Hepatitides, Drug-Induced//Hepatitis, Drug Induced

Expression Detail

GEO ID: GSE59565 Description: Circulating miRNAs of acetaminophen-overdosed patients Experimental Design: Accidental Acetaminophen Overdose Case Disease Type: Drug-induced Liver Injury Case Disease SubType: NA Case Sample: Healthy with APAP Overdose Control Sample: Healthy Number of Case: 18 Number of Control: 6 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACAP2 chr3 195274745 195443044 - ASB1 chr2 238426742 238452250 + BLCAP chr20 37492472 37527931 - CGN chr1 151510510 151538692 + FJX1 chr11 35618460 35620865 + GMCL1 chr2 69829660 69881384 + MIER3 chr5 56919602 56971675 - PFN1 chr17 4945652 4949061 - SIN3A chr15 75369379 75455842 - TRIM14 chr9 98069275 98119222 - ZCCHC2 chr18 62523025 62587709 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000417 chr12 69644908 69656342 + hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0000095 chr1 95609446 95616975 + hsa_circ_0000744 chr17 15968183 15971435 - hsa_circ_0000652 chr15 90984737 90986710 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC002044.1 chr16 73014319 73014476 - AC016876.2 chr17 7581964 7584086 - AC092718.4 chr16 81030770 81031485 + AL022311.1 chr22 37876148 37895563 + AL162258.1 chr1 153626332 153634340 - DLEU1 chr13 50082169 50906856 + GAS5 chr1 173858559 173868882 - LINC00641 chr14 21200079 21206900 - MALAT1 chr11 65497688 65506516 + MIR3142HG chr5 160438594 160487426 + NEAT1 chr11 65422774 65445540 + NR2F2-AS1 chr15 96110040 96327361 - OIP5-AS1 chr15 41283990 41309737 + SNHG1 chr11 62851984 62855953 - SNHG12 chr1 28578538 28583132 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE59565 Sample Source: Blood Source Fraction: Serum Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2545 Sample treatment protocol: Serum samples were recovered from serum-separator tubes following centrifugation of whole blood at 3000×g for 10 minutes at room temperature. RNA Extract protocol: Serum miRNA was isolated using the miRNeasy Mini Kit (QUIAGEN, CA, USA) RNA library preparation protocol: TruSeq Small RNA-Seq Preparation Kit (Illumina, CA, USA)

Reference

PMID: 25359176 Title: Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury Author: Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC Journal: Toxicol Sci. 2015 Feb;143(2):268-76. Description: Upon applying next generation high-throughput sequencing of small RNA libraries, 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs were relevant to APAP toxic mechanisms.