exRNAdisease

General Information

Database ID:

exR0286705

RNA Name:

hsa-miR-326

RNA Type:

miRNA

Chromosome:

chr11

Starnd:

Coordinate:

Start Site(bp):

75335108

End Site(bp):

75335127

External Links:

Disease Information

Disease Name:	Drug-induced Liver Injury
Disease Category:	Digestive System Diseases
MeSH ID:	D056486
Type:	Diseases Category/Digestive System Diseases
Alias:	Chemical and Drug Induced Liver Injury//Chemically-Induced Liver Toxicity//Chemically Induced Liver Toxicity//Chemically-Induced Liver Toxicities//Liver Toxicities, Chemically-Induced//Liver Toxicity, Chemically-Induced//Toxicities, Chemically-Induced Liver//Toxicity, Chemically-Induced Liver//Drug-Induced Acute Liver Injury//Drug Induced Acute Liver Injury//Liver Injury, Drug-Induced, Acute//Acute Liver Injury, Drug-Induced//Acute Liver Injury, Drug Induced//Hepatitis, Toxic//Toxic Hepatitis//Hepatitides, Toxic//Toxic Hepatitides//Drug-Induced Liver Disease//Disease, Drug-Induced Liver//Diseases, Drug-Induced Liver//Drug Induced Liver Disease//Drug-Induced Liver Diseases//Liver Disease, Drug-Induced//Liver Diseases, Drug-Induced//Drug-Induced Liver Injury//Drug Induced Liver Injury//Drug-Induced Liver Injuries//Injuries, Drug-Induced Liver//Injury, Drug-Induced Liver//Liver Injuries, Drug-Induced//Liver Injury, Drug-Induced//Liver Injury, Drug Induced//Hepatitis, Drug-Induced//Drug-Induced Hepatitides//Drug-Induced Hepatitis//Hepatitides, Drug-Induced//Hepatitis, Drug Induced

Expression Detail

GEO ID:	GSE59565
Description:	Circulating miRNAs of acetaminophen-overdosed patients
Experimental Design:	Accidental Acetaminophen Overdose
Case Disease Type:	Drug-induced Liver Injury
Case Disease SubType:	NA
Case Sample:	Healthy with APAP Overdose
Control Sample:	Healthy
Number of Case:	18
Number of Control:	6
Number of Samples:	24

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
DOLPP1	chr9	129081111	129090438	+
GOSR2	chr17	46923075	46975524	+
ITGA5	chr12	54395261	54419266	-
MAP4	chr3	47850690	48089272	-
NME4	chr16	396725	410367	+
PAQR4	chr16	2969270	2973484	+
RC3H1	chr1	173931084	174022357	-
REXO1	chr19	1815248	1848483	-
RTL10	chr22	19846138	19854896	-
STX3	chr11	59713456	59805882	+
TSPAN14	chr10	80454166	80533124	+

miRNA targets:

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0000128	chr1	151139409	151139890	+
hsa_circ_0000384	chr12	27867712	27877119	+
hsa_circ_0001727	chr7	99621041	99621930	+
hsa_circ_0001865	chr9	86292641	86293514	-

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC016876.2	chr17	7581964	7584086	-
AC144548.1	chr12	110387463	110445548	-
AL355075.4	chr14	20343048	20343685	-
AL359924.1	chr1	237862175	237928321	+
AP000553.1	chr22	21652270	21670237	+
KCNQ1OT1	chr11	2608328	2699994	-
MIRLET7BHG	chr22	46053869	46113928	+
NEAT1	chr11	65422774	65445540	+
SNHG1	chr11	62851984	62855953	-
SNHG3	chr1	28505980	28510892	+
TUG1	chr22	30969245	30979395	+
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE59565
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL11154
Method:	NGS
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	2545
Sample treatment protocol:	Serum samples were recovered from serum-separator tubes following centrifugation of whole blood at 3000×g for 10 minutes at room temperature.
RNA Extract protocol:	Serum miRNA was isolated using the miRNeasy Mini Kit (QUIAGEN, CA, USA)
RNA library preparation protocol:	TruSeq Small RNA-Seq Preparation Kit (Illumina, CA, USA)

Reference

PMID:	25359176
Title:	Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury
Author:	Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC
Journal:	Toxicol Sci. 2015 Feb;143(2):268-76.
Description:	Upon applying next generation high-throughput sequencing of small RNA libraries, 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs were relevant to APAP toxic mechanisms.