exRNAdisease

Entry Detail

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General Information

Database ID: exR0286720 RNA Name: hsa-miR-33b-5p RNA Type: miRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 17813897 End Site(bp): 17813916 External Links: hsa-miR-33b-5p

Disease Information

Disease Name: Drug-induced Liver Injury Disease Category: Digestive System Diseases MeSH ID: D056486 Type: Diseases Category/Digestive System Diseases Alias: Chemical and Drug Induced Liver Injury//Chemically-Induced Liver Toxicity//Chemically Induced Liver Toxicity//Chemically-Induced Liver Toxicities//Liver Toxicities, Chemically-Induced//Liver Toxicity, Chemically-Induced//Toxicities, Chemically-Induced Liver//Toxicity, Chemically-Induced Liver//Drug-Induced Acute Liver Injury//Drug Induced Acute Liver Injury//Liver Injury, Drug-Induced, Acute//Acute Liver Injury, Drug-Induced//Acute Liver Injury, Drug Induced//Hepatitis, Toxic//Toxic Hepatitis//Hepatitides, Toxic//Toxic Hepatitides//Drug-Induced Liver Disease//Disease, Drug-Induced Liver//Diseases, Drug-Induced Liver//Drug Induced Liver Disease//Drug-Induced Liver Diseases//Liver Disease, Drug-Induced//Liver Diseases, Drug-Induced//Drug-Induced Liver Injury//Drug Induced Liver Injury//Drug-Induced Liver Injuries//Injuries, Drug-Induced Liver//Injury, Drug-Induced Liver//Liver Injuries, Drug-Induced//Liver Injury, Drug-Induced//Liver Injury, Drug Induced//Hepatitis, Drug-Induced//Drug-Induced Hepatitides//Drug-Induced Hepatitis//Hepatitides, Drug-Induced//Hepatitis, Drug Induced

Expression Detail

GEO ID: GSE59565 Description: Circulating miRNAs of acetaminophen-overdosed patients Experimental Design: Accidental Acetaminophen Overdose Case Disease Type: Drug-induced Liver Injury Case Disease SubType: NA Case Sample: Healthy with APAP Overdose Control Sample: Healthy Number of Case: 18 Number of Control: 6 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ADCY9 chr16 3953387 4116442 - AFF4 chr5 132875395 132963634 - BTBD7 chr14 93237550 93333092 - CERK chr22 46684410 46738252 - CROT chr7 87345681 87399795 + DDX5 chr17 64498254 64508199 - E2F3 chr6 20401879 20493714 + ECHDC1 chr6 127288712 127343609 - EIF5A2 chr3 170888418 170908644 - IGF1R chr15 98648539 98964530 + IRS2 chr13 109752695 109786583 - MAPK1IP1L chr14 55051647 55070194 + MAPK6 chr15 51952106 52067375 + MTHFD2 chr2 74198610 74217565 + MYO19 chr17 36495633 36543435 - NAA15 chr4 139301505 139420033 + NFAT5 chr16 69565094 69704666 + PIM1 chr6 37170152 37175428 + RBM33 chr7 155644451 155781485 + RCAN1 chr21 34513142 34615113 - ROBO1 chr3 78597239 79767998 - SLC39A8 chr4 102251041 102431258 - SULF2 chr20 47656348 47786616 - TNPO1 chr5 72816312 72916733 + TPM1 chr15 63042632 63071915 + UBN2 chr7 139230356 139308236 + WDFY3 chr4 84669610 84966391 - XRN1 chr3 142306607 142448062 - ZFYVE16 chr5 80408013 80483379 + ZNF148 chr3 125225561 125375354 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001349 chr3 152132729 152150709 + hsa_circ_0000642 chr15 80390757 80415142 + hsa_circ_0000643 chr15 80412669 80415142 + hsa_circ_0000284 chr11 33307958 33309057 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC023509.1 chr12 53441741 53467528 + DANCR chr4 52712404 52720351 + FGD5-AS1 chr3 14920347 14948424 - MCF2L-AS1 chr13 112967484 112968824 - NEAT1 chr11 65422774 65445540 + Display:

Experiment Detail

GEO ID: GSE59565 Sample Source: Blood Source Fraction: Serum Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2545 Sample treatment protocol: Serum samples were recovered from serum-separator tubes following centrifugation of whole blood at 3000×g for 10 minutes at room temperature. RNA Extract protocol: Serum miRNA was isolated using the miRNeasy Mini Kit (QUIAGEN, CA, USA) RNA library preparation protocol: TruSeq Small RNA-Seq Preparation Kit (Illumina, CA, USA)

Reference

PMID: 25359176 Title: Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury Author: Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC Journal: Toxicol Sci. 2015 Feb;143(2):268-76. Description: Upon applying next generation high-throughput sequencing of small RNA libraries, 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs were relevant to APAP toxic mechanisms.