exRNAdisease

Entry Detail

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General Information

Database ID: exR0286751 RNA Name: hsa-miR-373-3p RNA Type: miRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 53788748 End Site(bp): 53788770 External Links: hsa-miR-373-3p

Disease Information

Disease Name: Drug-induced Liver Injury Disease Category: Digestive System Diseases MeSH ID: D056486 Type: Diseases Category/Digestive System Diseases Alias: Chemical and Drug Induced Liver Injury//Chemically-Induced Liver Toxicity//Chemically Induced Liver Toxicity//Chemically-Induced Liver Toxicities//Liver Toxicities, Chemically-Induced//Liver Toxicity, Chemically-Induced//Toxicities, Chemically-Induced Liver//Toxicity, Chemically-Induced Liver//Drug-Induced Acute Liver Injury//Drug Induced Acute Liver Injury//Liver Injury, Drug-Induced, Acute//Acute Liver Injury, Drug-Induced//Acute Liver Injury, Drug Induced//Hepatitis, Toxic//Toxic Hepatitis//Hepatitides, Toxic//Toxic Hepatitides//Drug-Induced Liver Disease//Disease, Drug-Induced Liver//Diseases, Drug-Induced Liver//Drug Induced Liver Disease//Drug-Induced Liver Diseases//Liver Disease, Drug-Induced//Liver Diseases, Drug-Induced//Drug-Induced Liver Injury//Drug Induced Liver Injury//Drug-Induced Liver Injuries//Injuries, Drug-Induced Liver//Injury, Drug-Induced Liver//Liver Injuries, Drug-Induced//Liver Injury, Drug-Induced//Liver Injury, Drug Induced//Hepatitis, Drug-Induced//Drug-Induced Hepatitides//Drug-Induced Hepatitis//Hepatitides, Drug-Induced//Hepatitis, Drug Induced

Expression Detail

GEO ID: GSE59565 Description: Circulating miRNAs of acetaminophen-overdosed patients Experimental Design: Accidental Acetaminophen Overdose Case Disease Type: Drug-induced Liver Injury Case Disease SubType: NA Case Sample: Healthy with APAP Overdose Control Sample: Healthy Number of Case: 18 Number of Control: 6 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand VLDLR chr9 2621787 2660056 + USP24 chr1 55066359 55215364 - CELF2 chr10 10798397 11336675 + APP chr21 25880550 26171128 - KLHL28 chr14 44924319 45042322 - RGMA chr15 93035273 93089204 - PFN2 chr3 149964904 150050788 - FAM177A1 chr14 35044907 35113130 + MBP chr18 76978827 77133683 - CUL1 chr7 148697914 148801110 + MSL1 chr17 40121971 40136917 + RIT1 chr1 155897808 155911404 - ATXN1 chr6 16299112 16761491 - ZFAND4 chr10 45615500 45672780 - SETD7 chr4 139495941 139606699 - BAZ1B chr7 73440406 73522293 - AMPD2 chr1 109616104 109632053 + SLC16A14 chr2 230034982 230068993 - PHC3 chr3 170086732 170181749 - FAM222B chr17 28755978 28855232 - PLEKHM1 chr17 45435900 45490749 - SYAP1 chrX 16719612 16765340 + ARL4A chr7 12686856 12690958 + RACGAP1 chr12 49976923 50033136 - LONP2 chr16 48244300 48363122 + CLIP4 chr2 29097705 29189643 + ADAR chr1 154582057 154628013 - MAGI3 chr1 113390515 113685923 + NAA16 chr13 41311267 41377030 + CLOCK chr4 55427903 55546909 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000943 chr19 47421744 47440665 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC125257.1 chr17 41848518 41851447 - AL049840.4 chr14 103694516 103695050 - ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - FGD5-AS1 chr3 14920347 14948424 - MIR17HG chr13 91347820 91354579 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE59565 Sample Source: Blood Source Fraction: Serum Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2545 Sample treatment protocol: Serum samples were recovered from serum-separator tubes following centrifugation of whole blood at 3000×g for 10 minutes at room temperature. RNA Extract protocol: Serum miRNA was isolated using the miRNeasy Mini Kit (QUIAGEN, CA, USA) RNA library preparation protocol: TruSeq Small RNA-Seq Preparation Kit (Illumina, CA, USA)

Reference

PMID: 25359176 Title: Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury Author: Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC Journal: Toxicol Sci. 2015 Feb;143(2):268-76. Description: Upon applying next generation high-throughput sequencing of small RNA libraries, 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs were relevant to APAP toxic mechanisms.