exRNAdisease

Entry Detail

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General Information

Database ID: exR0286944 RNA Name: hsa-miR-625-5p RNA Type: miRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 65471116 End Site(bp): 65471136 External Links: hsa-miR-625-5p

Disease Information

Disease Name: Drug-induced Liver Injury Disease Category: Digestive System Diseases MeSH ID: D056486 Type: Diseases Category/Digestive System Diseases Alias: Chemical and Drug Induced Liver Injury//Chemically-Induced Liver Toxicity//Chemically Induced Liver Toxicity//Chemically-Induced Liver Toxicities//Liver Toxicities, Chemically-Induced//Liver Toxicity, Chemically-Induced//Toxicities, Chemically-Induced Liver//Toxicity, Chemically-Induced Liver//Drug-Induced Acute Liver Injury//Drug Induced Acute Liver Injury//Liver Injury, Drug-Induced, Acute//Acute Liver Injury, Drug-Induced//Acute Liver Injury, Drug Induced//Hepatitis, Toxic//Toxic Hepatitis//Hepatitides, Toxic//Toxic Hepatitides//Drug-Induced Liver Disease//Disease, Drug-Induced Liver//Diseases, Drug-Induced Liver//Drug Induced Liver Disease//Drug-Induced Liver Diseases//Liver Disease, Drug-Induced//Liver Diseases, Drug-Induced//Drug-Induced Liver Injury//Drug Induced Liver Injury//Drug-Induced Liver Injuries//Injuries, Drug-Induced Liver//Injury, Drug-Induced Liver//Liver Injuries, Drug-Induced//Liver Injury, Drug-Induced//Liver Injury, Drug Induced//Hepatitis, Drug-Induced//Drug-Induced Hepatitides//Drug-Induced Hepatitis//Hepatitides, Drug-Induced//Hepatitis, Drug Induced

Expression Detail

GEO ID: GSE59565 Description: Circulating miRNAs of acetaminophen-overdosed patients Experimental Design: Accidental Acetaminophen Overdose Case Disease Type: Drug-induced Liver Injury Case Disease SubType: NA Case Sample: Healthy with APAP Overdose Control Sample: Healthy Number of Case: 18 Number of Control: 6 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand PPP2R1A chr19 52190048 52229518 + SF3B3 chr16 70523791 70577670 + LRFN1 chr19 39306568 39315336 - SLC6A6 chr3 14402576 14489349 + VPS37B chr12 122865330 122896127 - SMARCC2 chr12 56162359 56189567 - WIZ chr19 15419978 15449956 - SLC7A5 chr16 87830023 87869507 - MED22 chr9 133338312 133348131 - PPARD chr6 35342558 35428191 + FAM102A chr9 127940582 127980989 - ABL2 chr1 179099330 179229684 - PPP6C chr9 125146573 125189939 - ABCF2 chr7 151207837 151227166 - ABHD14A-ACY1 chr3 51974706 51989183 + BCL9L chr11 118893875 118925608 - JUN chr1 58780791 58784047 - NUMB chr14 73275107 73458617 - SDF2 chr17 28648346 28662189 - SREBF2 chr22 41833079 41907307 + COL6A2 chr21 46098112 46132848 + ACY1 chr3 51983340 51989197 + E2F1 chr20 33675477 33686385 - PRDX2 chr19 12796820 12801800 - MSI1 chr12 120341330 120369164 - COPS7B chr2 231781671 231809254 + CPSF7 chr11 61402641 61430031 - SCAMP4 chr19 1905372 1926013 + ITGA5 chr12 54395261 54419266 - RNF44 chr5 176526712 176538025 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001434 chr4 106345352 106377902 - hsa_circ_0001409 chr4 48835417 48859382 + hsa_circ_0001358 chr3 169694733 169706147 + hsa_circ_0001146 chr20 34241449 34246936 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010542.4 chr16 66549280 66551189 + AC145207.5 chr17 81878425 81881106 - AC234582.1 chr1 155195004 155205495 + H19 chr11 1995176 2001470 - LINC00240 chr6 26956932 27059749 + MALAT1 chr11 65497688 65506516 + SNHG7 chr9 136721366 136728184 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE59565 Sample Source: Blood Source Fraction: Serum Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2545 Sample treatment protocol: Serum samples were recovered from serum-separator tubes following centrifugation of whole blood at 3000×g for 10 minutes at room temperature. RNA Extract protocol: Serum miRNA was isolated using the miRNeasy Mini Kit (QUIAGEN, CA, USA) RNA library preparation protocol: TruSeq Small RNA-Seq Preparation Kit (Illumina, CA, USA)

Reference

PMID: 25359176 Title: Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury Author: Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC Journal: Toxicol Sci. 2015 Feb;143(2):268-76. Description: Upon applying next generation high-throughput sequencing of small RNA libraries, 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs were relevant to APAP toxic mechanisms.