exRNAdisease

Entry Detail

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General Information

Database ID: exR0286967 RNA Name: hsa-miR-654-5p RNA Type: miRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 101040234 End Site(bp): 101040255 External Links: hsa-miR-654-5p

Disease Information

Disease Name: Drug-induced Liver Injury Disease Category: Digestive System Diseases MeSH ID: D056486 Type: Diseases Category/Digestive System Diseases Alias: Chemical and Drug Induced Liver Injury//Chemically-Induced Liver Toxicity//Chemically Induced Liver Toxicity//Chemically-Induced Liver Toxicities//Liver Toxicities, Chemically-Induced//Liver Toxicity, Chemically-Induced//Toxicities, Chemically-Induced Liver//Toxicity, Chemically-Induced Liver//Drug-Induced Acute Liver Injury//Drug Induced Acute Liver Injury//Liver Injury, Drug-Induced, Acute//Acute Liver Injury, Drug-Induced//Acute Liver Injury, Drug Induced//Hepatitis, Toxic//Toxic Hepatitis//Hepatitides, Toxic//Toxic Hepatitides//Drug-Induced Liver Disease//Disease, Drug-Induced Liver//Diseases, Drug-Induced Liver//Drug Induced Liver Disease//Drug-Induced Liver Diseases//Liver Disease, Drug-Induced//Liver Diseases, Drug-Induced//Drug-Induced Liver Injury//Drug Induced Liver Injury//Drug-Induced Liver Injuries//Injuries, Drug-Induced Liver//Injury, Drug-Induced Liver//Liver Injuries, Drug-Induced//Liver Injury, Drug-Induced//Liver Injury, Drug Induced//Hepatitis, Drug-Induced//Drug-Induced Hepatitides//Drug-Induced Hepatitis//Hepatitides, Drug-Induced//Hepatitis, Drug Induced

Expression Detail

GEO ID: GSE59565 Description: Circulating miRNAs of acetaminophen-overdosed patients Experimental Design: Accidental Acetaminophen Overdose Case Disease Type: Drug-induced Liver Injury Case Disease SubType: NA Case Sample: Healthy with APAP Overdose Control Sample: Healthy Number of Case: 18 Number of Control: 6 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand BCL9L chr11 118893875 118925608 - ATP11A chr13 112690329 112887168 + PHB chr17 49404049 49414905 - ZDHHC3 chr3 44915257 44976185 - PKM chr15 72199029 72231822 - ATXN7L3 chr17 44191805 44200113 - SH3PXD2A chr10 103594027 103855543 - ITGA5 chr12 54395261 54419266 - TP53 chr17 7661779 7687550 - CBFA2T3 chr16 88874858 88977207 - CS chr12 56271699 56300391 - LY6E chr8 143017982 143023832 + SPINT1 chr15 40844018 40858207 + AGTRAP chr1 11736084 11754802 + URM1 chr9 128371361 128392016 + BCL7A chr12 122019422 122062044 + MEF2D chr1 156463727 156500779 - DHCR24 chr1 54849627 54887195 - JADE2 chr5 134524312 134583230 + LSM12 chr17 44034328 44067619 - ZMIZ1 chr10 79068966 79316528 + TOB2 chr22 41433494 41446801 - ACTN4 chr19 38647649 38731589 + XPO6 chr16 28097979 28211920 - KMT2D chr12 49018975 49059774 - SMAD3 chr15 67063763 67195169 + BCAM chr19 44809071 44821421 + IGF2BP1 chr17 48997385 49056145 + GID4 chr17 18039408 18068405 + NID1 chr1 235975830 236065109 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000417 chr12 69644908 69656342 + hsa_circ_0000642 chr15 80390757 80415142 + hsa_circ_0000816 chr17 80521229 80526077 + hsa_circ_0000643 chr15 80412669 80415142 + hsa_circ_0000943 chr19 47421744 47440665 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC239868.1 chr1 149861271 149862504 + AL035458.2 chr20 34234840 34281173 - AL356488.2 chr1 109100193 109100619 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - OIP5-AS1 chr15 41283990 41309737 + STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE59565 Sample Source: Blood Source Fraction: Serum Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2545 Sample treatment protocol: Serum samples were recovered from serum-separator tubes following centrifugation of whole blood at 3000×g for 10 minutes at room temperature. RNA Extract protocol: Serum miRNA was isolated using the miRNeasy Mini Kit (QUIAGEN, CA, USA) RNA library preparation protocol: TruSeq Small RNA-Seq Preparation Kit (Illumina, CA, USA)

Reference

PMID: 25359176 Title: Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury Author: Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC Journal: Toxicol Sci. 2015 Feb;143(2):268-76. Description: Upon applying next generation high-throughput sequencing of small RNA libraries, 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs were relevant to APAP toxic mechanisms.