exRNAdisease

Entry Detail

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General Information

Database ID: exR0287001 RNA Name: hsa-miR-744-5p RNA Type: miRNA Chromosome: chr17 Starnd: + Coordinate: Start Site(bp): 12081909 End Site(bp): 12081930 External Links: hsa-miR-744-5p

Disease Information

Disease Name: Drug-induced Liver Injury Disease Category: Digestive System Diseases MeSH ID: D056486 Type: Diseases Category/Digestive System Diseases Alias: Chemical and Drug Induced Liver Injury//Chemically-Induced Liver Toxicity//Chemically Induced Liver Toxicity//Chemically-Induced Liver Toxicities//Liver Toxicities, Chemically-Induced//Liver Toxicity, Chemically-Induced//Toxicities, Chemically-Induced Liver//Toxicity, Chemically-Induced Liver//Drug-Induced Acute Liver Injury//Drug Induced Acute Liver Injury//Liver Injury, Drug-Induced, Acute//Acute Liver Injury, Drug-Induced//Acute Liver Injury, Drug Induced//Hepatitis, Toxic//Toxic Hepatitis//Hepatitides, Toxic//Toxic Hepatitides//Drug-Induced Liver Disease//Disease, Drug-Induced Liver//Diseases, Drug-Induced Liver//Drug Induced Liver Disease//Drug-Induced Liver Diseases//Liver Disease, Drug-Induced//Liver Diseases, Drug-Induced//Drug-Induced Liver Injury//Drug Induced Liver Injury//Drug-Induced Liver Injuries//Injuries, Drug-Induced Liver//Injury, Drug-Induced Liver//Liver Injuries, Drug-Induced//Liver Injury, Drug-Induced//Liver Injury, Drug Induced//Hepatitis, Drug-Induced//Drug-Induced Hepatitides//Drug-Induced Hepatitis//Hepatitides, Drug-Induced//Hepatitis, Drug Induced

Expression Detail

GEO ID: GSE59565 Description: Circulating miRNAs of acetaminophen-overdosed patients Experimental Design: Accidental Acetaminophen Overdose Case Disease Type: Drug-induced Liver Injury Case Disease SubType: NA Case Sample: Healthy with APAP Overdose Control Sample: Healthy Number of Case: 18 Number of Control: 6 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AP5S1 chr20 3820524 3828838 + ARHGDIA chr17 81867721 81871378 - ARL8A chr1 202133404 202144743 - C8orf82 chr8 144525733 144529132 - CLSTN1 chr1 9728926 9823984 - CMIP chr16 81445170 81711762 + DLGAP4 chr20 36306336 36528637 + DNAJC30 chr7 73680918 73683453 - EEF1A2 chr20 63488014 63499185 - FAM219A chr9 34398184 34458570 - FAM83H chr8 143723933 143738234 - MGRN1 chr16 4616493 4690974 + MIDN chr19 1248553 1259140 + NFIX chr19 12995608 13098796 + NRARP chr9 137299631 137302271 - PHB2 chr12 6965327 6970753 - PRKCD chr3 53156009 53192717 + PRR12 chr19 49591182 49626439 + RAI14 chr5 34656328 34832612 + SCN1B chr19 35030470 35040449 + SH3GL1 chr19 4360370 4400547 - SMAD3 chr15 67063763 67195169 + SPRED2 chr2 65310851 65432637 - SYVN1 chr11 65121780 65134533 - WNT5A chr3 55465715 55490539 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC002116.1 chr19 36008638 36014235 - AC008738.7 chr19 33207129 33207639 + AL356488.2 chr1 109100193 109100619 + GAS5 chr1 173858559 173868882 - Display:

Experiment Detail

GEO ID: GSE59565 Sample Source: Blood Source Fraction: Serum Platform: GPL11154 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2545 Sample treatment protocol: Serum samples were recovered from serum-separator tubes following centrifugation of whole blood at 3000×g for 10 minutes at room temperature. RNA Extract protocol: Serum miRNA was isolated using the miRNeasy Mini Kit (QUIAGEN, CA, USA) RNA library preparation protocol: TruSeq Small RNA-Seq Preparation Kit (Illumina, CA, USA)

Reference

PMID: 25359176 Title: Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury Author: Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC Journal: Toxicol Sci. 2015 Feb;143(2):268-76. Description: Upon applying next generation high-throughput sequencing of small RNA libraries, 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs were relevant to APAP toxic mechanisms.