exRNAdisease

General Information

Database ID:

exR0287005

RNA Name:

hsa-miR-769-5p

RNA Type:

miRNA

Chromosome:

chr19

Starnd:

Coordinate:

Start Site(bp):

46018961

End Site(bp):

46018982

External Links:

Disease Information

Disease Name:	Drug-induced Liver Injury
Disease Category:	Digestive System Diseases
MeSH ID:	D056486
Type:	Diseases Category/Digestive System Diseases
Alias:	Chemical and Drug Induced Liver Injury//Chemically-Induced Liver Toxicity//Chemically Induced Liver Toxicity//Chemically-Induced Liver Toxicities//Liver Toxicities, Chemically-Induced//Liver Toxicity, Chemically-Induced//Toxicities, Chemically-Induced Liver//Toxicity, Chemically-Induced Liver//Drug-Induced Acute Liver Injury//Drug Induced Acute Liver Injury//Liver Injury, Drug-Induced, Acute//Acute Liver Injury, Drug-Induced//Acute Liver Injury, Drug Induced//Hepatitis, Toxic//Toxic Hepatitis//Hepatitides, Toxic//Toxic Hepatitides//Drug-Induced Liver Disease//Disease, Drug-Induced Liver//Diseases, Drug-Induced Liver//Drug Induced Liver Disease//Drug-Induced Liver Diseases//Liver Disease, Drug-Induced//Liver Diseases, Drug-Induced//Drug-Induced Liver Injury//Drug Induced Liver Injury//Drug-Induced Liver Injuries//Injuries, Drug-Induced Liver//Injury, Drug-Induced Liver//Liver Injuries, Drug-Induced//Liver Injury, Drug-Induced//Liver Injury, Drug Induced//Hepatitis, Drug-Induced//Drug-Induced Hepatitides//Drug-Induced Hepatitis//Hepatitides, Drug-Induced//Hepatitis, Drug Induced

Expression Detail

GEO ID:	GSE59565
Description:	Circulating miRNAs of acetaminophen-overdosed patients
Experimental Design:	Accidental Acetaminophen Overdose
Case Disease Type:	Drug-induced Liver Injury
Case Disease SubType:	NA
Case Sample:	Healthy with APAP Overdose
Control Sample:	Healthy
Number of Case:	18
Number of Control:	6
Number of Samples:	24

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ACVR1B	chr12	51951699	51997078	+
ANGEL1	chr14	76786168	76826246	-
ASB1	chr2	238426742	238452250	+
BMPR2	chr2	202376327	202567751	+
CAPNS1	chr19	36139953	36150353	+
CBFB	chr16	67028984	67101058	+
CLDN11	chr3	170418865	170454733	+
CLN8	chr8	1755778	1801711	+
DBNDD1	chr16	90004871	90020128	-
DCTN4	chr5	150708440	150759109	-
EIF1AD	chr11	65996545	66002176	-
EIF1AX	chrX	20124525	20141838	-
FOXK1	chr7	4682295	4771442	+
LONRF2	chr2	100271875	100322501	-
MDM4	chr1	204516379	204558120	+
MRTO4	chr1	19251805	19260128	+
NUSAP1	chr15	41320794	41381050	+
PLCD3	chr17	45108959	45133354	-
PRKAA1	chr5	40759379	40798374	-
PXN	chr12	120210439	120265771	-
RHPN1	chr8	143368876	143384221	+
RUNX1	chr21	34787801	36004667	-
TFAP4	chr16	4257186	4273075	-
VAT1	chr17	43014607	43025123	-
YPEL5	chr2	30146941	30160533	+
ZDHHC9	chrX	129803288	129843909	-

miRNA targets:

circRNA targets:

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC245033.4	chr15	82533175	82540008	-
LINC00324	chr17	8220642	8224043	-
MALAT1	chr11	65497688	65506516	+
SNHG1	chr11	62851984	62855953	-

Display:

Experiment Detail

GEO ID:	GSE59565
Sample Source:	Blood
Source Fraction:	Serum
Platform:	GPL11154
Method:	NGS
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	2545
Sample treatment protocol:	Serum samples were recovered from serum-separator tubes following centrifugation of whole blood at 3000×g for 10 minutes at room temperature.
RNA Extract protocol:	Serum miRNA was isolated using the miRNeasy Mini Kit (QUIAGEN, CA, USA)
RNA library preparation protocol:	TruSeq Small RNA-Seq Preparation Kit (Illumina, CA, USA)

Reference

PMID:	25359176
Title:	Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury
Author:	Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC
Journal:	Toxicol Sci. 2015 Feb;143(2):268-76.
Description:	Upon applying next generation high-throughput sequencing of small RNA libraries, 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs were relevant to APAP toxic mechanisms.