Entry Detail



General Information

Database ID:exR0357696
RNA Name:hsa-miR-513a-5p
RNA Type:miRNA
Chromosome:chrX
Starnd:-
Coordinate:
Start Site(bp):147213538End Site(bp):147213555
External Links:hsa-miR-513a-5p



Disease Information

Disease Name:Breast Cancer
Disease Category:Cancers
MeSH ID:D001943
Type:Neoplasms/Breast Neoplasms
Alias:Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast



Expression Detail

GEO ID:GSE98181
Description:Circulating miRNA profiles from serum of women at high-risk for breast cancer
Experimental Design:Cancer vs Control
Case Disease Type:Breast Cancer
Case Disease SubType:NA
Case Sample:Breast Cancer
Control Sample:Healthy
Number of Case:24
Number of Control:24
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AEN
chr15
88621337
88632281
+
CD276
chr15
73683966
73714514
+
FAM168B
chr2
131047876
131093460
-
GIPC1
chr19
14477760
14496149
-
IGF2BP3
chr7
23310209
23470491
-
ILF3
chr19
10654261
10692417
+
JRK
chr8
142657460
142681968
-
KCTD21
chr11
78171249
78188626
-
KIAA0232
chr4
6781375
6884170
+
MET
chr7
116672196
116798386
+
MTCL1
chr18
8705661
8832778
+
NRBP1
chr2
27427790
27442259
+
PA2G4
chr12
56104537
56113910
+
PAK1
chr11
77321707
77474635
-
PLK2
chr5
58453982
58460139
-
PPP1CC
chr12
110719680
110742939
-
PRLR
chr5
35048756
35230487
-
RHOU
chr1
228735479
228746664
+
SNX27
chr1
151612006
151699091
+
SOX11
chr2
5692384
5701385
+
SS18
chr18
26016253
26091217
-
STRBP
chr9
123109500
123268586
-
TMX4
chr20
7977346
8019805
-
TXN2
chr22
36467046
36481640
-
WASL
chr7
123681943
123749003
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000894
chr19
12825634
12826553
-
hsa_circ_0000540
chr14
55799534
55821940
+
hsa_circ_0001005
chr2
53921020
53978078
-
hsa_circ_0001168
chr20
47691321
47707559
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC009133.5
chr16
29808679
29812227
+
AC023509.1
chr12
53441741
53467528
+
AC095055.1
chr4
151139991
151141103
+
AC239868.1
chr1
149861271
149862504
+
CYTOR
chr2
87454781
87636740
+
KCNQ1OT1
chr11
2608328
2699994
-
LINC01578
chr15
92819540
92899701
+
MIR4435-2HG
chr2
111006015
111523376
-
MIR663AHG
chr20
26167817
26251546
-
NEAT1
chr11
65422774
65445540
+
OIP5-AS1
chr15
41283990
41309737
+
SNHG16
chr17
76557764
76565348
+
SNHG20
chr17
77086716
77099902
+
Display:



Experiment Detail

GEO ID:GSE98181
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21572
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2546
Sample treatment protocol:Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes.
RNA Extract protocol:RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water.
RNA library preparation protocol:Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.



Reference

PMID:29348816
Title:Development of a predictive miRNA signature for breast cancer risk among high-risk women.
Author:Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME
Journal:Oncotarget. 2017 Nov 28;8(68):112170-112183.
Description:We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.