exRNAdisease

Entry Detail

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General Information

Database ID: exR0358065 RNA Name: hsa-miR-625-5p RNA Type: miRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 65471116 End Site(bp): 65471136 External Links: hsa-miR-625-5p

Disease Information

Disease Name: Breast Cancer Disease Category: Cancers MeSH ID: D001943 Type: Neoplasms/Breast Neoplasms Alias: Breast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

Expression Detail

GEO ID: GSE98181 Description: Circulating miRNA profiles from serum of women at high-risk for breast cancer Experimental Design: Cancer vs Control Case Disease Type: Breast Cancer Case Disease SubType: NA Case Sample: Breast Cancer Control Sample: Healthy Number of Case: 24 Number of Control: 24 Number of Samples: 48

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand PPP2R1A chr19 52190048 52229518 + SF3B3 chr16 70523791 70577670 + LRFN1 chr19 39306568 39315336 - SLC6A6 chr3 14402576 14489349 + VPS37B chr12 122865330 122896127 - SMARCC2 chr12 56162359 56189567 - WIZ chr19 15419978 15449956 - SLC7A5 chr16 87830023 87869507 - MED22 chr9 133338312 133348131 - PPARD chr6 35342558 35428191 + FAM102A chr9 127940582 127980989 - ABL2 chr1 179099330 179229684 - PPP6C chr9 125146573 125189939 - ABCF2 chr7 151207837 151227166 - ABHD14A-ACY1 chr3 51974706 51989183 + BCL9L chr11 118893875 118925608 - JUN chr1 58780791 58784047 - NUMB chr14 73275107 73458617 - SDF2 chr17 28648346 28662189 - SREBF2 chr22 41833079 41907307 + COL6A2 chr21 46098112 46132848 + ACY1 chr3 51983340 51989197 + E2F1 chr20 33675477 33686385 - PRDX2 chr19 12796820 12801800 - MSI1 chr12 120341330 120369164 - COPS7B chr2 231781671 231809254 + CPSF7 chr11 61402641 61430031 - SCAMP4 chr19 1905372 1926013 + ITGA5 chr12 54395261 54419266 - RNF44 chr5 176526712 176538025 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001434 chr4 106345352 106377902 - hsa_circ_0001409 chr4 48835417 48859382 + hsa_circ_0001358 chr3 169694733 169706147 + hsa_circ_0001146 chr20 34241449 34246936 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010542.4 chr16 66549280 66551189 + AC145207.5 chr17 81878425 81881106 - AC234582.1 chr1 155195004 155205495 + H19 chr11 1995176 2001470 - LINC00240 chr6 26956932 27059749 + MALAT1 chr11 65497688 65506516 + SNHG7 chr9 136721366 136728184 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE98181 Sample Source: Blood Source Fraction: Serum Platform: GPL21572 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2546 Sample treatment protocol: Serum is obtained from coagulated whole blood samples by centrifugation at 3000 rpm for 10 minutes. RNA Extract protocol: RNA was isolated from a 200ul serum aliquot using the miRNeasy Serum Plasma kit with ce-miR-39 spike-in (QIAGEN), QIAcube (QIAGEN) automation, and eluted with 14uL of nuclease-free water. RNA library preparation protocol: Exactly 8ul of RNA was tagged with a Poly-A tail, using an ATP driven reaction from the Affymetrix® FlashTag™ Biotin HSR RNA Labeling Kit.

Reference

PMID: 29348816 Title: Development of a predictive miRNA signature for breast cancer risk among high-risk women. Author: Farina NH, Ramsey JE, Cuke ME, Ahern TP, Shirley DJ, Stein JL, Stein GS, Lian JB, Wood ME Journal: Oncotarget. 2017 Nov 28;8(68):112170-112183. Description: We evaluated the ability of C-miRNAs to identify women most likely to develop breast cancer by profiling miRNA from serum obtained long before diagnosis.