Entry Detail


General Information

Database ID:exR0358722
RNA Name:hsa-let-7a-3p
RNA Type:miRNA
Chromosome:chr22
Starnd:+
Coordinate:
Start Site(bp):46112800End Site(bp):46112820
External Links:hsa-let-7a-3p



Disease Information

Disease Name:Newborn Infant
Disease Category:Other Diseases
MeSH ID:D007231
Type:Age Groups/Infant
Alias:Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates



Expression Detail

GEO ID:GSE65203
Description:microRNA as a new immune-regulatory agent in breast milk
Experimental Design:Disease vs Control
Case Disease Type:Newborn Infant
Case Disease SubType:NA
Case Sample:Deliver < 28 days
Control Sample:Deliver > 28 days
Number of Case:2
Number of Control:4
Number of Samples:6





Regulatory Relationship

mRNA targets:NA
miRNA targets:NA
circRNA targets:NA
lncRNA targets:NA
Display:N/A



Experiment Detail

GEO ID:GSE65203
Sample Source:Breast Milk
Source Fraction:Supernatant
Platform:GPL7731
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:548
Sample treatment protocol:NA
RNA Extract protocol:Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions.
RNA library preparation protocol:70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.



Reference

PMID:20226005
Title:microRNA as a new immune-regulatory agent in breast milk
Author:Kosaka N, Izumi H, Sekine K, Ochiya T.
Journal:Silence. 2010 Mar 1;1(1):7.
Description:BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.