Entry Detail



General Information

Database ID:exR0358728
RNA Name:hsa-let-7d-5p
RNA Type:miRNA
Chromosome:chr9
Starnd:+
Coordinate:
Start Site(bp):94178841End Site(bp):94178862
External Links:hsa-let-7d-5p



Disease Information

Disease Name:Newborn Infant
Disease Category:Other Diseases
MeSH ID:D007231
Type:Age Groups/Infant
Alias:Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates



Expression Detail

GEO ID:GSE65203
Description:microRNA as a new immune-regulatory agent in breast milk
Experimental Design:Disease vs Control
Case Disease Type:Newborn Infant
Case Disease SubType:NA
Case Sample:Deliver < 28 days
Control Sample:Deliver > 28 days
Number of Case:2
Number of Control:4
Number of Samples:6





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
TECPR2
chr14
102362941
102502477
+
DDB2
chr11
47214465
47239240
+
RPL41
chr12
56116590
56117967
+
ZCCHC9
chr5
81301587
81313297
+
BCAM
chr19
44809071
44821421
+
BACH1
chr21
29194071
29630751
+
HMGA2
chr12
65824131
65966295
+
PLPP6
chr9
4662294
4665258
+
CSNK1E
chr22
38290691
38318084
-
ACTG1
chr17
81509971
81523847
-
CTPS2
chrX
16587999
16712936
-
YOD1
chr1
207043849
207052980
-
SH3PXD2B
chr5
172325000
172454525
-
BLOC1S6
chr15
45587214
45615945
+
C15orf41
chr15
36579626
36810248
+
GRPEL2
chr5
149345430
149354583
+
ACP1
chr2
264140
278283
+
IGF2BP1
chr17
48997385
49056145
+
MNT
chr17
2384073
2401104
-
PPARA
chr22
46150521
46243756
+
PRMT1
chr19
49675786
49689029
+
IGDCC3
chr15
65327127
65378002
-
ARID3B
chr15
74541177
74598131
+
TRIM65
chr17
75880335
75896951
-
HMGCS1
chr5
43287470
43313512
-
VPS26C
chr21
37223420
37267919
-
DHX15
chr4
24517441
24584554
-
HMGA1
chr6
34236873
34246231
+
HDLBP
chr2
241227264
241317061
-
UBE2G2
chr21
44768580
44801826
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000247
chr10
74474868
74475660
+
hsa_circ_0000987
chr2
30748452
30756180
+
hsa_circ_0000246
chr10
74468040
74475660
+
hsa_circ_0000018
chr1
15860731
15863309
+
hsa_circ_0000038
chr1
28800065
28802803
+
hsa_circ_0000799
chr17
65941524
65972074
+
hsa_circ_0001164
chr20
45891031
45923523
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC006064.5
chr12
6510275
6510522
+
AC074117.1
chr2
27356246
27367622
+
AC109460.3
chr16
28974804
28990775
+
AC124045.1
chr3
44667412
44669364
+
AP000766.1
chr11
107312132
107316271
-
ARHGAP27P1-BPTFP1-KPNA2P3
chr17
64749663
64781707
-
KCNQ1OT1
chr11
2608328
2699994
-
LINC00265
chr7
39733430
39793092
+
LINC02381
chr12
54126082
54147485
+
MIRLET7BHG
chr22
46053869
46113928
+
NEAT1
chr11
65422774
65445540
+
NUTM2A-AS1
chr10
87201647
87342612
-
SNHG16
chr17
76557764
76565348
+
SNHG4
chr5
139274102
139284899
+
TMPO-AS1
chr12
98512973
98516422
-
XIST
chrX
73820649
73852723
-
ZNF436-AS1
chr1
23368997
23371839
+
LINC01001
chr11
127204
139612
-
Display:



Experiment Detail

GEO ID:GSE65203
Sample Source:Breast Milk
Source Fraction:Supernatant
Platform:GPL7731
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:548
Sample treatment protocol:NA
RNA Extract protocol:Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions.
RNA library preparation protocol:70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.



Reference

PMID:20226005
Title:microRNA as a new immune-regulatory agent in breast milk
Author:Kosaka N, Izumi H, Sekine K, Ochiya T.
Journal:Silence. 2010 Mar 1;1(1):7.
Description:BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.