exRNAdisease

General Information

Database ID:

exR0358733

RNA Name:

hsa-let-7f-5p

RNA Type:

miRNA

Chromosome:

chrX

Starnd:

Coordinate:

Start Site(bp):

53557246

End Site(bp):

53557267

External Links:

Disease Information

Disease Name:	Newborn Infant
Disease Category:	Other Diseases
MeSH ID:	D007231
Type:	Age Groups/Infant
Alias:	Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID:	GSE65203
Description:	microRNA as a new immune-regulatory agent in breast milk
Experimental Design:	Disease vs Control
Case Disease Type:	Newborn Infant
Case Disease SubType:	NA
Case Sample:	Deliver < 28 days
Control Sample:	Deliver > 28 days
Number of Case:	2
Number of Control:	4
Number of Samples:	6

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ACP1	chr2	264140	278283	+
ARHGAP28	chr18	6729718	6915716	+
BLOC1S6	chr15	45587214	45615945	+
CTPS2	chrX	16587999	16712936	-
EEA1	chr12	92770637	92929331	-
GRPEL2	chr5	149345430	149354583	+
HDLBP	chr2	241227264	241317061	-
HMGA2	chr12	65824131	65966295	+
IGF2BP1	chr17	48997385	49056145	+
NHLRC3	chr13	39038306	39050109	+
PDPR	chr16	70113626	70162537	+
PHC3	chr3	170086732	170181749	-
RANBP2	chr2	108719482	108785809	+
RNH1	chr11	494512	507300	-
TBC1D13	chr9	128787253	128810430	+
TRIM65	chr17	75880335	75896951	-
UBE2G2	chr21	44768580	44801826	-
ACTG1	chr17	81509971	81523847	-
C18orf21	chr18	35972625	35979286	+
FAM162A	chr3	122384176	122412334	+
GSTO1	chr10	104235356	104267459	+
HLA-DQA2	chr6	32741391	32747198	+
LONP1	chr19	5691834	5720572	-
PFKFB4	chr3	48517684	48562015	-

miRNA targets:

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0000247	chr10	74474868	74475660	+
hsa_circ_0000987	chr2	30748452	30756180	+
hsa_circ_0000246	chr10	74468040	74475660	+
hsa_circ_0000018	chr1	15860731	15863309	+
hsa_circ_0000038	chr1	28800065	28802803	+
hsa_circ_0000799	chr17	65941524	65972074	+
hsa_circ_0001164	chr20	45891031	45923523	-

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC006064.5	chr12	6510275	6510522	+
AC074117.1	chr2	27356246	27367622	+
AC109460.3	chr16	28974804	28990775	+
AC124045.1	chr3	44667412	44669364	+
AP000766.1	chr11	107312132	107316271	-
ARHGAP27P1-BPTFP1-KPNA2P3	chr17	64749663	64781707	-
KCNQ1OT1	chr11	2608328	2699994	-
LINC00265	chr7	39733430	39793092	+
LINC02381	chr12	54126082	54147485	+
MIRLET7BHG	chr22	46053869	46113928	+
NEAT1	chr11	65422774	65445540	+
NUTM2A-AS1	chr10	87201647	87342612	-
SNHG16	chr17	76557764	76565348	+
SNHG4	chr5	139274102	139284899	+
TMPO-AS1	chr12	98512973	98516422	-
XIST	chrX	73820649	73852723	-
ZNF436-AS1	chr1	23368997	23371839	+

Display:

Experiment Detail

GEO ID:	GSE65203
Sample Source:	Breast Milk
Source Fraction:	Supernatant
Platform:	GPL7731
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	548
Sample treatment protocol:	NA
RNA Extract protocol:	Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions.
RNA library preparation protocol:	70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID:	20226005
Title:	microRNA as a new immune-regulatory agent in breast milk
Author:	Kosaka N, Izumi H, Sekine K, Ochiya T.
Journal:	Silence. 2010 Mar 1;1(1):7.
Description:	BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.