exRNAdisease

Entry Detail

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General Information

Database ID: exR0358787 RNA Name: hsa-miR-138-5p RNA Type: miRNA Chromosome: chr16 Starnd: + Coordinate: Start Site(bp): 56858527 End Site(bp): 56858549 External Links: hsa-miR-138-5p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand KRT80 chr12 52168996 52192014 - STX3 chr11 59713456 59805882 + SIN3A chr15 75369379 75455842 - RNH1 chr11 494512 507300 - ACTN4 chr19 38647649 38731589 + CDCA7L chr7 21900899 21945903 - COPS7B chr2 231781671 231809254 + LARP4B chr10 806914 931705 - GSK3A chr19 42230190 42242625 - GNAI2 chr3 50226292 50259362 + NINJ1 chr9 93121496 93134251 - IGF2BP1 chr17 48997385 49056145 + TFAP2A chr6 10393186 10419659 - FOXC1 chr6 1609915 1613897 + PATL1 chr11 59636716 59669037 - SRF chr6 43171269 43181506 + MAFG chr17 81918270 81927735 - AHDC1 chr1 27534035 27604431 - FOXP4 chr6 41546426 41602384 + HIF1AN chr10 100529072 100559998 + PRKACA chr19 14091688 14118084 - SMG1 chr16 18804853 18926454 - IQGAP1 chr15 90388242 90502239 + CTDSP1 chr2 218398256 218405941 + HMGA1 chr6 34236873 34246231 + KLF11 chr2 10042849 10054836 + ZHX2 chr8 122781655 122974510 + IQSEC1 chr3 12897043 13283281 - PLXNB2 chr22 50274979 50307646 - TRIB1 chr8 125430358 125438403 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0000402 chr12 53670403 53671011 + hsa_circ_0000798 chr17 65941524 65944422 + hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0000799 chr17 65941524 65972074 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC092718.4 chr16 81030770 81031485 + AC144548.1 chr12 110387463 110445548 - AL137127.1 chr1 19072110 19075511 - H19 chr11 1995176 2001470 - MCF2L-AS1 chr13 112967484 112968824 - MCM3AP-AS1 chr21 46229196 46259390 + NEAT1 chr11 65422774 65445540 + PARD6G-AS1 chr18 80147924 80179839 + STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + TUG1 chr22 30969245 30979395 + TFAP2A-AS1 chr6 10409340 10416446 + Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.