exRNAdisease

Entry Detail

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General Information

Database ID: exR0358815 RNA Name: hsa-miR-17-5p RNA Type: miRNA Chromosome: chr13 Starnd: + Coordinate: Start Site(bp): 91350618 End Site(bp): 91350640 External Links: hsa-miR-17-5p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CLOCK chr4 55427903 55546909 - CDK6 chr7 92604921 92836594 - WASF3 chr13 26557683 26688948 + ELF1 chr13 40931924 41061440 - FCF1 chr14 74713144 74738620 + WDR37 chr10 1049538 1132384 + ZDHHC12 chr9 128720870 128724127 - LDLRAD3 chr11 35943981 36232136 + ZSCAN26 chr6 28267010 28278224 + NUDT21 chr16 56429133 56452199 - SCAMP2 chr15 74843730 74873365 - MAGI3 chr1 113390515 113685923 + C9orf40 chr9 74946583 74952912 - PTP4A1 chr6 63521746 63583436 + CUL1 chr7 148697914 148801110 + SENP1 chr12 48042897 48106079 - PBXIP1 chr1 154944076 154956123 - ATXN1 chr6 16299112 16761491 - PXDN chr2 1631887 1744852 - ZNF587 chr19 57849859 57865117 + LONP2 chr16 48244300 48363122 + APP chr21 25880550 26171128 - SLC16A9 chr10 59650761 59736002 - ADNP chr20 50888916 50931437 - NAA16 chr13 41311267 41377030 + NSD2 chr4 1871393 1982207 + AMPD2 chr1 109616104 109632053 + WDR36 chr5 111091716 111130502 + ARMC8 chr3 138187248 138298384 + ADARB1 chr21 45073853 45226560 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001495 chr5 68470703 68471364 + hsa_circ_0000494 chr13 76134888 76143643 + hsa_circ_0000018 chr1 15860731 15863309 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC015871.3 chr15 79920195 79922455 - AC021078.1 chr5 149494314 149504670 - AC021092.1 chr19 44103007 44113183 - AC024940.6 chr12 31280422 31280895 - AC084082.1 chr8 66112667 66126632 + AC087477.2 chr15 96354237 96405235 + AC243964.3 chr19 44631573 44725217 - AL031428.1 chr1 23020147 23088058 - AL137782.1 chr13 75549773 75807120 + AL158206.1 chr9 19453209 19455173 + AL161772.1 chr13 20699307 20703718 - ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - CKMT2-AS1 chr5 81201341 81301565 - EPB41L4A-AS1 chr5 112160526 112164818 + ERICD chr8 140636281 140638283 + FGD5-AS1 chr3 14920347 14948424 - H19 chr11 1995176 2001470 - HAGLR chr2 176164051 176188958 - HOTAIR chr12 53962308 53974956 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.