exRNAdisease

Entry Detail

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General Information

Database ID: exR0358850 RNA Name: hsa-miR-200a-3p RNA Type: miRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 1167916 End Site(bp): 1167937 External Links: hsa-miR-200a-3p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ANP32E chr1 150218417 150236156 - ARPC5 chr1 183620846 183635783 - GALNT10 chr5 154190730 154420984 + KRT10 chr17 40818117 40822614 - PDHA1 chrX 19343893 19361718 + PIGW chr17 36534987 36539310 + QKI chr6 163414000 163578592 + QSER1 chr11 32892820 32993316 + RMND5A chr2 86720291 86778041 + TNRC6B chr22 40044817 40335808 + C6orf62 chr6 24704861 24719998 - PLAG1 chr8 56160909 56211324 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001329 chr3 119219541 119222868 + hsa_circ_0001376 chr3 194169185 194175121 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016831.1 chr7 130876809 130913310 - AC023509.1 chr12 53441741 53467528 + AC234582.1 chr1 155195004 155205495 + AL049840.4 chr14 103694516 103695050 - MALAT1 chr11 65497688 65506516 + MIR29B2CHG chr1 207801518 207879115 - NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + PINK1-AS chr1 20642657 20652193 - SNHG15 chr7 44983023 44986961 - SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.