exRNAdisease

Entry Detail

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General Information

Database ID: exR0358873 RNA Name: hsa-miR-224-5p RNA Type: miRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 151958628 End Site(bp): 151958652 External Links: hsa-miR-224-5p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand C19orf47 chr19 40319536 40348527 - DPYSL2 chr8 26514031 26658178 + INO80D chr2 205993721 206086303 - PITPNA chr17 1517718 1562792 - TFB1M chr6 155256134 155314493 - GABRE chrX 151953124 151974680 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001025 chr2 69565029 69565697 - hsa_circ_0001495 chr5 68470703 68471364 + hsa_circ_0001085 chr2 191765289 191789319 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AL137127.1 chr1 19072110 19075511 - AL158206.1 chr9 19453209 19455173 + LINC00205 chr21 45288050 45297806 + LINC00665 chr19 36313067 36331770 - MALAT1 chr11 65497688 65506516 + MCM3AP-AS1 chr21 46229196 46259390 + NEAT1 chr11 65422774 65445540 + Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.