exRNAdisease

Entry Detail

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General Information

Database ID: exR0358899 RNA Name: hsa-miR-302a-3p RNA Type: miRNA Chromosome: chr4 Starnd: - Coordinate: Start Site(bp): 112648186 End Site(bp): 112648208 External Links: hsa-miR-302a-3p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ZBTB5 chr9 37438102 37465450 - PPP1R8 chr1 27830782 27851676 + ATP6V1C1 chr8 103021063 103073051 + SEC23B chr20 18507520 18561415 + FABP5 chr8 81280536 81284777 + THRAP3 chr1 36224432 36305357 + LONP2 chr16 48244300 48363122 + KLC1 chr14 103561896 103714249 + FAM222B chr17 28755978 28855232 - WASF3 chr13 26557683 26688948 + TOP2A chr17 40388525 40417896 - APP chr21 25880550 26171128 - ARL4A chr7 12686856 12690958 + PDRG1 chr20 31944337 31952046 - SCAMP2 chr15 74843730 74873365 - RAB31 chr18 9708275 9862551 + IKZF4 chr12 56007659 56038435 + RACGAP1 chr12 49976923 50033136 - MGLL chr3 127689062 128052190 - HABP4 chr9 96450169 96491336 + USP6NL chr10 11453946 11611754 - RGMA chr15 93035273 93089204 - JARID2 chr6 15246069 15522042 + BAZ1B chr7 73440406 73522293 - CLIP4 chr2 29097705 29189643 + IPO7 chr11 9384652 9448127 + SEC23IP chr10 119892730 119944657 + VLDLR chr9 2621787 2660056 + IZUMO2 chr19 50152548 50163195 - SSR1 chr6 7268306 7347446 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000943 chr19 47421744 47440665 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC011503.2 chr19 23927788 23929287 + AC125257.1 chr17 41848518 41851447 - AL049840.4 chr14 103694516 103695050 - ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - FGD5-AS1 chr3 14920347 14948424 - MIR17HG chr13 91347820 91354579 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.