exRNAdisease

Entry Detail

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General Information

Database ID: exR0359017 RNA Name: hsa-miR-513a-5p RNA Type: miRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 147213538 End Site(bp): 147213555 External Links: hsa-miR-513a-5p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AEN chr15 88621337 88632281 + CD276 chr15 73683966 73714514 + FAM168B chr2 131047876 131093460 - GIPC1 chr19 14477760 14496149 - IGF2BP3 chr7 23310209 23470491 - ILF3 chr19 10654261 10692417 + JRK chr8 142657460 142681968 - KCTD21 chr11 78171249 78188626 - KIAA0232 chr4 6781375 6884170 + MET chr7 116672196 116798386 + MTCL1 chr18 8705661 8832778 + NRBP1 chr2 27427790 27442259 + PA2G4 chr12 56104537 56113910 + PAK1 chr11 77321707 77474635 - PLK2 chr5 58453982 58460139 - PPP1CC chr12 110719680 110742939 - PRLR chr5 35048756 35230487 - RHOU chr1 228735479 228746664 + SNX27 chr1 151612006 151699091 + SOX11 chr2 5692384 5701385 + SS18 chr18 26016253 26091217 - STRBP chr9 123109500 123268586 - TMX4 chr20 7977346 8019805 - TXN2 chr22 36467046 36481640 - WASL chr7 123681943 123749003 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000894 chr19 12825634 12826553 - hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001005 chr2 53921020 53978078 - hsa_circ_0001168 chr20 47691321 47707559 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009133.5 chr16 29808679 29812227 + AC023509.1 chr12 53441741 53467528 + AC095055.1 chr4 151139991 151141103 + AC239868.1 chr1 149861271 149862504 + CYTOR chr2 87454781 87636740 + KCNQ1OT1 chr11 2608328 2699994 - LINC01578 chr15 92819540 92899701 + MIR4435-2HG chr2 111006015 111523376 - MIR663AHG chr20 26167817 26251546 - NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + SNHG16 chr17 76557764 76565348 + SNHG20 chr17 77086716 77099902 + Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.