exRNAdisease

Entry Detail

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General Information

Database ID: exR0359042 RNA Name: hsa-miR-520b-3p RNA Type: miRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 53701267 End Site(bp): 53701287 External Links: hsa-miR-520b-3p

Disease Information

Disease Name: Newborn Infant Disease Category: Other Diseases MeSH ID: D007231 Type: Age Groups/Infant Alias: Infant, Newborn//Infants, Newborn//Newborn Infant//Newborn Infants//Newborns//Newborn//Neonate//Neonates

Expression Detail

GEO ID: GSE65203 Description: microRNA as a new immune-regulatory agent in breast milk Experimental Design: Disease vs Control Case Disease Type: Newborn Infant Case Disease SubType: NA Case Sample: Deliver < 28 days Control Sample: Deliver > 28 days Number of Case: 2 Number of Control: 4 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TNS1 chr2 217799588 218033982 - CLCN6 chr1 11806096 11848079 + SIRPA chr20 1894167 1940592 + CELF2 chr10 10798397 11336675 + MBP chr18 76978827 77133683 - PLAGL2 chr20 32192504 32207743 - APP chr21 25880550 26171128 - KLHL28 chr14 44924319 45042322 - SEC16A chr9 136440096 136483759 - CCDC93 chr2 117915478 118014133 - MAGI3 chr1 113390515 113685923 + PTP4A1 chr6 63521746 63583436 + SYAP1 chrX 16719612 16765340 + SEMA3C chr7 80742538 80922359 - ADAR chr1 154582057 154628013 - CUL1 chr7 148697914 148801110 + CHD9 chr16 53055033 53329150 + TRIB1 chr8 125430358 125438403 + SLC16A14 chr2 230034982 230068993 - IFNAR1 chr21 33324429 33359864 + WDR82 chr3 52254434 52288020 - RUNDC1 chr17 42980565 42993690 + NPAS2 chr2 100820139 100996829 + JPT1 chr17 75135248 75168281 - LONP2 chr16 48244300 48363122 + OCRL chrX 129539849 129592561 + ZFAND4 chr10 45615500 45672780 - PHC3 chr3 170086732 170181749 - ATXN1 chr6 16299112 16761491 - FAM177A1 chr14 35044907 35113130 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL049840.4 chr14 103694516 103695050 - ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - FGD5-AS1 chr3 14920347 14948424 - MIR17HG chr13 91347820 91354579 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE65203 Sample Source: Breast Milk Source Fraction: Supernatant Platform: GPL7731 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 548 Sample treatment protocol: NA RNA Extract protocol: Total RNA extracted using mirVana miRNA isolation kit following manufacturer's instructions. RNA library preparation protocol: 70 ng of each RNA sample was labeled with the miRNA Complete Labeling Reagent and Hybridization kit (Agilent Technologies) according to the manufacturer's instructions.

Reference

PMID: 20226005 Title: microRNA as a new immune-regulatory agent in breast milk Author: Kosaka N, Izumi H, Sekine K, Ochiya T. Journal: Silence. 2010 Mar 1;1(1):7. Description: BACKGROUND: Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system.