exRNAdisease

Entry Detail

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General Information

Database ID: exR0359187 RNA Name: AAGAB RNA Type: mRNA Chromosome: chr15 Starnd: - Coordinate: Start Site(bp): 67200667 End Site(bp): 67255195 External Links: ENSG00000103591

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand BTBD1 chr15 83016423 83067252 - PIMREG chr17 6444441 6451469 + HNRNPA1 chr12 54280193 54287088 + SETD1A chr16 30957754 30984664 + RAC3 chr17 82031678 82034204 + ARF4 chr3 57571363 57598220 - RPL27 chr17 42998273 43002959 + HSDL1 chr16 84122141 84145192 - CHD7 chr8 60678740 60868028 + CRABP2 chr1 156699606 156705816 - DUT chr15 48331011 48343373 + UNC119B chr12 120710458 120723640 + PRDM2 chr1 13700198 13825079 + BCAP31 chrX 153700492 153724565 - TOMM20 chr1 235109341 235128837 - CDPF1 chr22 46244011 46250311 - MRPL45 chr17 38297023 38323217 + CHMP3 chr2 86503430 86563479 - RPS23 chr5 82273320 82278396 - RTN4 chr2 54972187 55112621 - CCND2 chr12 4273762 4305353 + FUS chr16 31180110 31194871 + YWHAQ chr2 9583967 9630997 - PFN1 chr17 4945652 4949061 - GPAM chr10 112149865 112215377 - HYAL2 chr3 50317790 50322782 - R3HDM1 chr2 135531455 135725270 + FTL chr19 48965309 48966879 + RPL10A chr6 35468401 35470785 + RIC1 chr9 5629025 5776557 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand HLA-F-AS1 chr6 29726601 29749049 - PARD6G-AS1 chr18 80147924 80179839 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.