exRNAdisease

Entry Detail

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General Information

Database ID: exR0359192 RNA Name: AAR2 RNA Type: mRNA Chromosome: chr20 Starnd: + Coordinate: Start Site(bp): 36236459 End Site(bp): 36270918 External Links: ENSG00000131043

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MCM3AP chr21 46235133 46286297 - PLCB2 chr15 40278176 40307935 - MANBAL chr20 37289638 37317260 + LDHA chr11 18394560 18408425 + DHX15 chr4 24517441 24584554 - YWHAH chr22 31944522 31957603 + M6PR chr12 8940361 8949761 - LSS chr21 46188141 46228824 - MTHFR chr1 11785723 11806455 - EGLN2 chr19 40798996 40808434 + COX6B1 chr19 35648323 35658782 + PKP2 chr12 32790745 32896840 - TEN1-CDK3 chr17 75979231 76005999 + TMEM47 chrX 34627075 34657285 - HMOX2 chr16 4474690 4510347 + BRF1 chr14 105209286 105315589 - CCDC77 chr12 389273 442642 + DDX17 chr22 38483438 38507660 - NELFE chr6 31952087 31959038 - PAGR1 chr16 29816152 29822489 + LMTK2 chr7 98106862 98209638 + RAB4B-EGLN2 chr19 40778242 40808418 + HNRNPH3 chr10 68331174 68343191 + ACTR1A chr10 102461881 102502712 - CANX chr5 179678628 179731641 + MCM7 chr7 100092728 100101940 - RPL3 chr22 39312882 39320389 - FLII chr17 18244815 18258738 - TUBA1A chr12 49184795 49189080 - PAICS chr4 56435741 56464579 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-103a-3p chr5 168560904 168560926 - hsa-miR-147a chr9 120244985 120245004 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand EBLN3P chr9 37079645 37090928 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.