exRNAdisease

Entry Detail

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General Information

Database ID: exR0359195 RNA Name: AARSD1 RNA Type: mRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 42950526 End Site(bp): 42964498 External Links: ENSG00000266967

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand PTMS chr12 6765516 6770952 + KBTBD7 chr13 41189834 41194569 - PPDPF chr20 63520765 63522206 + PPP1CC chr12 110719680 110742939 - BLOC1S5-TXNDC5 chr6 7881522 8064364 - ZNF777 chr7 149431363 149461062 - CALM3 chr19 46601074 46610782 + HIGD2A chr5 176388751 176389761 + RPL35A chr3 197950190 197956610 + HNRNPF chr10 43385617 43409166 - CCNT2 chr2 134918235 134959342 + ERI2 chr16 20780193 20900349 - RPUSD3 chr3 9837849 9844602 - TPT1 chr13 45333471 45341370 - RNPS1 chr16 2253116 2268397 - CALR chr19 12938578 12944489 + PTGES3L-AARSD1 chr17 42950526 42980528 - RNF213 chr17 80260866 80398786 + SASH3 chrX 129779949 129795201 + EDARADD chr1 236348257 236502915 + CST3 chr20 23626706 23638473 - SKI chr1 2228319 2310213 + MRPL13 chr8 120380761 120445402 - TMEM258 chr11 61768501 61792802 - ASB8 chr12 48147789 48181213 - RPL27 chr17 42998273 43002959 + GSPT2 chrX 51743442 51746232 + TXNDC5 chr6 7881517 7910788 - DYNLL1 chr12 120469850 120498493 + TRMU chr22 46330875 46357340 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand Z95114.1 chr22 36071000 36085573 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.