exRNAdisease

Entry Detail

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General Information

Database ID: exR0359197 RNA Name: AASDHPPT RNA Type: mRNA Chromosome: chr11 Starnd: + Coordinate: Start Site(bp): 106075501 End Site(bp): 106098699 External Links: ENSG00000149313

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand GTF2F2 chr13 45120510 45284893 + CFL1 chr11 65823022 65862026 - NUP93 chr16 56730118 56850286 + HSD17B8 chr6 33204655 33206831 + RPL3 chr22 39312882 39320389 - RASSF3 chr12 64507001 64697564 + TMBIM6 chr12 49707725 49764934 + HNRNPL chr19 38836388 38852347 - CXXC4 chr4 104468308 104494901 - PSME3 chr17 42824385 42843760 + AHCY chr20 34280268 34311802 - ESRP1 chr8 94641074 94707466 + AKAP10 chr17 19904302 19978343 - PCLAF chr15 64364304 64387687 - COA3 chr17 42795147 42798704 - MTA2 chr11 62593214 62601865 - EIF4G2 chr11 10797050 10808940 - WDR73 chr15 84639281 84654343 - PUM2 chr2 20248691 20352234 - GTPBP6 chrX 304529 318819 - NAP1L4 chr11 2944431 2992377 - MATR3 chr5 139273752 139331671 + IRF7 chr11 612553 615983 - SINHCAF chr12 31280584 31327058 - RAB8A chr19 16111889 16134234 + SPG21 chr15 64963022 64990310 - PANK3 chr5 168548495 168579368 - DIAPH1 chr5 141515016 141619055 - RPS29 chr14 49570984 49599164 - HMGA1 chr6 34236873 34246231 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC064807.1 chr8 51899268 51949874 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.