exRNAdisease

Entry Detail

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General Information

Database ID: exR0359203 RNA Name: ABCA2 RNA Type: mRNA Chromosome: chr9 Starnd: - Coordinate: Start Site(bp): 137007234 End Site(bp): 137028922 External Links: ENSG00000107331

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand STK11 chr19 1177558 1228431 + SLC36A4 chr11 93144174 93197991 - KBTBD11 chr8 1973677 2006936 + BMP2K chr4 78776342 78916372 + EXOC7 chr17 76081016 76121576 - SMG5 chr1 156249224 156282825 - SPECC1L chr22 24270817 24417739 + XXYLT1 chr3 195068284 195271159 - NIP7 chr16 69337996 69343106 + MYL5 chr4 673580 682033 + RBPJ chr4 26163455 26435131 + REEP5 chr5 112876385 112922289 - GANAB chr11 62624826 62646726 - DDX6 chr11 118747763 118791164 - METTL26 chr16 634427 636366 - ACAP3 chr1 1292390 1309609 - LRP5 chr11 68312591 68449275 + SUPT5H chr19 39436156 39476670 + MCM2 chr3 127598410 127622436 + HNRNPK chr9 83968083 83980616 - FLNA chrX 154348524 154374638 - SRRM2 chr16 2752626 2772538 + POMGNT1 chr1 46188682 46220305 - PLXNA1 chr3 126988594 127037392 + HDGFL3 chr15 83112738 83207823 - YWHAQ chr2 9583967 9630997 - LMAN2 chr5 177331567 177351668 - HECA chr6 139135080 139180802 + SEC24C chr10 73744372 73772161 + EXTL3 chr8 28600469 28755599 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-1286 chr22 20249145 20249165 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AC067930.1 chr8 143579636 143580670 + AD000090.1 chr19 35557956 35581954 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.