exRNAdisease

Entry Detail

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General Information

Database ID: exR0359204 RNA Name: ABCA3 RNA Type: mRNA Chromosome: chr16 Starnd: - Coordinate: Start Site(bp): 2275881 End Site(bp): 2340746 External Links: ENSG00000167972

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ATG2B chr14 96279195 96363341 - BCAR1 chr16 75228181 75268053 - LAMB2 chr3 49121114 49133118 - HLA-F chr6 29722775 29738528 + NOC4L chr12 132144457 132152473 + HS3ST3A1 chr17 13494032 13601929 - ASRGL1 chr11 62337448 62393412 + HNRNPUL2-BSCL2 chr11 62690275 62727384 - SIK3 chr11 116843402 117098437 - MCMBP chr10 119829404 119892556 - CYB5R3 chr22 42617840 42649392 - RPL11 chr1 23691742 23696835 + KLHL21 chr1 6590724 6614607 - PVRIG chr7 100218241 100221490 + ZNF219 chr14 21090077 21104722 - PKM chr15 72199029 72231822 - HMGB2 chr4 173331376 173334432 - DNAJC18 chr5 139408588 139444491 - MT-ND4L chrMT 10470 10766 + CHTF18 chr16 788046 800737 + CDH4 chr20 61252261 61940617 + TSC2 chr16 2047967 2089491 + CDCA2 chr8 25459199 25507911 + TPRN chr9 137191617 137204193 - HLA-E chr6 30489509 30494194 + DCP2 chr5 112976702 113022195 + FAM104A chr17 73207353 73236753 - BUB3 chr10 123154402 123170467 + RFWD3 chr16 74621399 74666877 - TUBB2A chr6 3153666 3157544 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC022167.2 chr16 8848105 8860456 + AC245014.3 chr1 145281116 145281462 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.