exRNAdisease

Entry Detail

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General Information

Database ID: exR0359208 RNA Name: ABCA7 RNA Type: mRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 1039997 End Site(bp): 1065572 External Links: ENSG00000064687

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC008982.1 chr19 38817471 38840178 - AGPAT2 chr9 136673143 136687457 - ANP32E chr1 150218417 150236156 - ATP2B4 chr1 203626561 203744081 + CCNE1 chr19 29811991 29824312 + CD99 chrX 2691187 2741309 + EIF4G3 chr1 20806292 21176888 - FAM50A chrX 154444141 154450654 + GNB1 chr1 1785285 1891117 - HMGXB3 chr5 150000046 150053142 + HNRNPL chr19 38836388 38852347 - ILF3 chr19 10654261 10692417 + LRRK1 chr15 100919327 101078257 + MDH2 chr7 76048051 76067508 + METTL24 chr6 110245928 110358272 - MPG chr16 77007 85853 + MT-CO1 chrMT 5904 7445 + MTRNR2L8 chr11 10507894 10509186 - PARP6 chr15 72241181 72272999 - SLC29A2 chr11 66362521 66372214 - SNX17 chr2 27370496 27377535 + SRSF1 chr17 58000919 58007346 - TMCO3 chr13 113491021 113554590 + TMEM201 chr1 9588911 9614877 + TMEM69 chr1 45688181 45694436 + TNKS chr8 9555912 9782346 + TSPAN3 chr15 77041404 77083984 - TUBA1A chr12 49184795 49189080 - ZNF200 chr16 3222325 3236221 - ZNF800 chr7 127346790 127431924 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand LINC01783 chr1 16533886 16536172 - SNHG17 chr20 38419638 38435409 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.