exRNAdisease

Entry Detail

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General Information

Database ID: exR0359211 RNA Name: ABCB10 RNA Type: mRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 229516582 End Site(bp): 229558707 External Links: ENSG00000135776

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand PKN1 chr19 14433053 14471867 + HELQ chr4 83407343 83455855 - MBOAT7 chr19 54173412 54189882 - RPL32 chr3 12834485 12841582 - DUSP16 chr12 12473282 12562863 - CBX6 chr22 38861422 38872249 - FOXK1 chr7 4682295 4771442 + NISCH chr3 52455118 52493068 + MTA1 chr14 105419820 105470729 + METTL9 chr16 21597218 21657473 + ESPL1 chr12 53268299 53293638 + NPHP4 chr1 5862811 5992473 - GAREM1 chr18 32124877 32470882 - RPS3 chr11 75399515 75422280 + NELL2 chr12 44508275 44921848 - VPS13D chr1 12230030 12512047 + BRWD1 chr21 39184176 39321559 - PRELID1 chr5 177303799 177306949 + NAT10 chr11 34105617 34147670 + HTATSF1 chrX 136497079 136512346 + GAN chr16 81314966 81380198 + PUS3 chr11 125893485 125903221 - CLPTM1 chr19 44954585 44993341 + DPP9 chr19 4675224 4724673 - CCZ1 chr7 5898725 5926550 + SLC37A4 chr11 119024114 119030906 - MLEC chr12 120687149 120701859 + BRSK2 chr11 1389899 1462689 + MAP4 chr3 47850690 48089272 - PI4KB chr1 151291797 151327715 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand SNHG4 chr5 139274102 139284899 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.